Chronic Frustrated Immune Response Flashcards Preview

Lindsey's Blood and Lymph Unit III > Chronic Frustrated Immune Response > Flashcards

Flashcards in Chronic Frustrated Immune Response Deck (34)
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1

HLA-Cw*06:02 is associated with ____.

psoriasis

2

How are harmful responses prevented and the gut simultaneously protected?

Treg and Tfh reside in the Peyer's Patches; they can interconvert into one another as needed

3

What is the genetic association found in Celiac Disease?

90% of pts have HLA-DQ2 allele

4

IL-23 is associated with ____.

psoriasis

5

What does the combination of TGFβ + IL-6 do?

downregulates Treg and upregulates Th1, Th2, and Th17

6

What would happen if the Treg response was too strong?

appropriate responses to viruses and bacteria would be suppressed

7

What allele is associated with Chronic Beryllium Disease?

HLA-DP

7

What is the Old Friends Hypothesis?

harmless microorganisms are important to prevent the immune system from responding too strongly to a non-threat; based on proper Treg balance

8

What cells make IL-6 and why?

epithelial and other cells; in response to stress or damage

9

What are the genetic associations in Crohn's and Ulcerative Colitis?

several loci ID'd to correlate to disease; concordinance in twin studies; early genetic event causes increase in gut permeability so defensins, made by the gut, penetrate back into the tissues and act as DAMPs

10

How is TG2 an antigen in Celiac Disease?

it couples to but can't release gliadin, thereby making a B-cell autoantigen, and T-cells respond to this foreign + self hybrid

10

IL-6 and TGFβ are found together in pathogenesis of _____ and _____.

Inflammatory Bowel Disease, Periodontal Disease

11

HLA-DQ2 is associated with ______.

Celiac Disease

12

What allele is associated with psoriasis?

HLA-Cw*06:02

15

In response to stress or damage, epi and other cells secrete ____.

IL-6

16

Which cytokine is implicated as pathogenic in psoriasis?

IL-23 from Th17

17

Name 2 hypotheses as to why there has been an increase in allergic responses and autoimmune diseases.

1. Hygeine Hypothesis 2. Old Friends Hypothesis

18

How do T0s differentiate into Tregs?

when TGFβ is present

18

Which cytokines are present in Periodontal Disease?

IL-6 and TGFβ

19

What is the antigen in Celiac Disease?

tissue transglutaminase 2 (TG2)

20

What is the Hygeine Hypothesis?

exposure to environmental dirt and infections helps the immune system properly develop; otherwise Th2 dominates the system

22

What immunoglobulin do the Peyer's Patches resident B cell make?

IgA

23

What cells make IL-10, and what does it do?

dendritic cells; stimulates Treg development

24

How were whipworms shown to help UC and Crohns pts?

pts ingested harmless worm ova, which increased Treg cells in the gut, thereby suppressing Th1, Th2, and Th17 and relieving symptoms

25

What is tissue transglutaminase 2 (TG2)?

the antigen in Celiac disease

26

What is Chronic Beryllium Disease?

pulmonary inflammation and fibrosis from beryllium dust inhalation

27

How does beryllium become antigenic in the lungs?

it covalently links to peptides, making novel epitopes that activate Th1 and maybe Th17, and later Th2

28

How can the gut revert to normal in Celiac Disease?

avoidance of gluten

29

What are Peyer's Patches?

clumps of lymphoid nodules in the ileum that are full of immune cells

30

What cytokine is in abundance in the Peyer's Patches?

TGFβ