____ is a T-cell marker that highlights abundant T-cells in the paracortex and scatter T-cells in the germinal center.
What is MCL?
B-cell neoplasm of small to medium-sized lymphocytes
What is MGUS?
monoclonal Ig in the serum or urine in pt w/o evidence of plasma cell neoplasms
In FL, the B cells will express _____, _____, _____, ____, and _____.
CD19, CD20, BCL2, CD10, BCL6
The ______ pattern is seen in BL.
What is solitary plasmacytoma of bone?
localized tumor of bone, composed of clonal plasma cells similar to those in plasma cell myeloma
What is BCL2?
an oncogene that induces follicular lymphoid hyperplasia
B-cells in MCL typically express ____, ____, and ____ but do not express ____.
CD19, CD20, CD5; CD23
What is Hodgkin's Lymphoma?
4 types of germinal center B-cell neoplasms; Reed-Sternberg cells are diagnostic
The ____ deletion is the most common genetic alteration in CLL and has a favorable prognosis.
Translocations of the _____ on chromosome 8 at band 8q24 are a constant feature of Burkitt's Lymphoma.
What is Burkitt's Lymphoma?
highly aggressive B-cell lymphoma, presenting as extranodal sites or a leukemic form
MCL is characterized by the _____ gene rearrangement at _____, leading to a constant overexpression of cyclin D1.
CLL will have B-cells positive for ____, ____, and ____.
CD5, CD23, CD19
What does NSHL stand for?
nodular sclerosis CHL
What are the most frequent s/s of plasma cell neoplasms?
bone pain the back or extremities, weakness, tiredness, anemia
What does NLPHL stand for?
nodular lymphocyte-predominant Hodgkin's Lymphoma
What are the 4 subtypes of Classical Hodgkin's Lymphoma (CHLs)?
1. nodular sclerosis classical Hodgkin's Lymphoma 2. lymphocyte-rich classical Hodgkin's Lymphoma 3. mixed cellularity classical Hodgkin's Lymphoma 4. lymphocyte-depleted classical Hodgkin's Lymphoma
What is cyclin D1?
it's important in tumor development
Endemic BL can affect the ____ and _____ bones, and the _____, ____, and _____.
jaw; other facial; distal ileum, cecum, omentum
What is a Reed-Sternberg cell?
large, up to 100microm, multiple or lobated nuclei; ample cytoplasm
Efferent means ____.
What is a plasma cell myeloma?
bone marrow based, multifocal plasma cell neoplasm that shows M protein in serum or urine
What are the diagnostic criteria of MGUS?
M component less than myeloma levels; marrow plasmacytosis
Tumor cells in HL express ____ and ____ but lack ____.
CD30, CD15; CD45
What does FL stand for?
Where do 75% of all extraosseous plasmacytomas appear?
upper respiratory tract, including nasal passages, sinuses, oropharynx, and larynx
What is found in the 2a lymphoid follicle's mantle zone?
small cells that surround the germinal center
What is the average age of diagnosis of MCL?
Most plasma cell neoplasms originate as ____, but can occasionally present as ____.
bone marrow tumors; extramedullary sites