Overview of Lymphoid Neoplasms/Hodgkin and non-Hodgkin Flashcards Preview

Lindsey's Blood and Lymph Unit III > Overview of Lymphoid Neoplasms/Hodgkin and non-Hodgkin > Flashcards

Flashcards in Overview of Lymphoid Neoplasms/Hodgkin and non-Hodgkin Deck (65)
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1

____ is a T-cell marker that highlights abundant T-cells in the paracortex and scatter T-cells in the germinal center.

CD3

1

What is MCL?

B-cell neoplasm of small to medium-sized lymphocytes

1

What is MGUS?

monoclonal Ig in the serum or urine in pt w/o evidence of plasma cell neoplasms

2

In FL, the B cells will express _____, _____, _____, ____, and _____.

CD19, CD20, BCL2, CD10, BCL6

3

The ______ pattern is seen in BL.

starry-sky

3

What is solitary plasmacytoma of bone?

localized tumor of bone, composed of clonal plasma cells similar to those in plasma cell myeloma

5

What is BCL2?

an oncogene that induces follicular lymphoid hyperplasia

5

B-cells in MCL typically express ____, ____, and ____ but do not express ____.

CD19, CD20, CD5; CD23

6

What is Hodgkin's Lymphoma?

4 types of germinal center B-cell neoplasms; Reed-Sternberg cells are diagnostic

7

The ____ deletion is the most common genetic alteration in CLL and has a favorable prognosis.

13q14

8

Translocations of the _____ on chromosome 8 at band 8q24 are a constant feature of Burkitt's Lymphoma.

MYC oncogene

9

What is Burkitt's Lymphoma?

highly aggressive B-cell lymphoma, presenting as extranodal sites or a leukemic form

10

MCL is characterized by the _____ gene rearrangement at _____, leading to a constant overexpression of cyclin D1.

BCL1; 11q13

11

CLL will have B-cells positive for ____, ____, and ____.

CD5, CD23, CD19

12

What does NSHL stand for?

nodular sclerosis CHL

13

What are the most frequent s/s of plasma cell neoplasms?

bone pain the back or extremities, weakness, tiredness, anemia

13

What does NLPHL stand for?

nodular lymphocyte-predominant Hodgkin's Lymphoma

14

What are the 4 subtypes of Classical Hodgkin's Lymphoma (CHLs)?

1. nodular sclerosis classical Hodgkin's Lymphoma 2. lymphocyte-rich classical Hodgkin's Lymphoma 3. mixed cellularity classical Hodgkin's Lymphoma 4. lymphocyte-depleted classical Hodgkin's Lymphoma

15

What is cyclin D1?

it's important in tumor development

15

Endemic BL can affect the ____ and _____ bones, and the _____, ____, and _____.

jaw; other facial; distal ileum, cecum, omentum

15

What is a Reed-Sternberg cell?

large, up to 100microm, multiple or lobated nuclei; ample cytoplasm

17

Efferent means ____.

away

18

What is a plasma cell myeloma?

bone marrow based, multifocal plasma cell neoplasm that shows M protein in serum or urine

19

What are the diagnostic criteria of MGUS?

M component less than myeloma levels; marrow plasmacytosis

20

Tumor cells in HL express ____ and ____ but lack ____.

CD30, CD15; CD45

21

What does FL stand for?

follicular lymphoma

22

Where do 75% of all extraosseous plasmacytomas appear?

upper respiratory tract, including nasal passages, sinuses, oropharynx, and larynx

23

What is found in the 2a lymphoid follicle's mantle zone?

small cells that surround the germinal center

24

What is the average age of diagnosis of MCL?

60yo

25

Most plasma cell neoplasms originate as ____, but can occasionally present as ____.

bone marrow tumors; extramedullary sites