Immunopathology Type 1, Allergies Flashcards Preview

Lindsey's Blood and Lymph Unit III > Immunopathology Type 1, Allergies > Flashcards

Flashcards in Immunopathology Type 1, Allergies Deck (16)
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1

What fights parasites in the body?

Th2, IgE, IgG

2

What is IgG's role in fighting worms?

binds the worm or ova and activates complement

3

What happens when neutrophils respond to the opsonized worms?

nothing- they lack a helminthocidal mechanism

4

How are mast cells activate by worms?

worms secrete antigen that diffuse to the mast cells, activating them

5

How does mast cell degranulation help fight worms?

histamine causes smooth muscle contraction; violent peristalsis expels the worms

6

What do mast cells secrete to attract eos?

prostaglandins and leukotrienes

7

Why do mast cells secrete prostaglandins and leukotrienes?

to attract eos

8

What happens when an eosinophil engages an IgG opsonized worm?

it releases its granules, including Major Basic Protein

9

What is Major Basic Protein?

a granule secreted by eos that is highly toxic to helminths

10

What is the Th2's role in worm fighting?

it attracts both eos and macs and secretes IL-4, 5, and 13 to convert the macs to M2 macs

11

Why do Th2 cells convert macs into M2 macs in worm infections?

to heal damage and wall off the worm

12

____ binds strongly to the FceR1 receptors on mast cells.

IgE

13

IgE binds strongly to the _____ on mast cells.

FceR1 receptors

14

IgE binds strongly to the FceR1 receptors on ____.

mast cells

15

When _____ are cross linked by an allergen, the mast cell degranulates.

2 adjacent bound IgE molecules

16

When 2 adjacent bound IgE molecules are cross linked by an allergen, _____.

the mast cell degranulates