Lymphoid Neoplasms: Follicular Lymphoma and DBCL Flashcards Preview

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Flashcards in Lymphoid Neoplasms: Follicular Lymphoma and DBCL Deck (10)
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1

Follicular Lymphoma staining

Bcl-2

2

Larger cells seen in follicular lymphomas indicate what about the lymphoma?

It has a worse prognosis

3

Where are the neoplastic cells in follicular lymphoma located?

germinal center

4

Nodular infiltrate of small, cleaved lymphocytes w/ admixed large cells, incomplete mantle zone or no mantla zone at all as well as lack of tingible body macrophages allow us to distinguish follicular lymphoma from

reactive lymphoid tissue

5

Genetics of Follicular Lymphoma

t(14;18): overexpression of Bcl-2

6

Diffuse Large B cell lymphoma presents frequently w/ what sort of nodal findings

extranodal presentation

7

Diffuse Large B cell lymphoma is aggressive or not aggressive?

Aggressive

8

CD markers for Diffuse Large B cell lymphoma

CD 19+, CD20+, CD10+/-, CD5-, slg + (clonal)

9

CD markers for Follicular Lymphoma

CD19+, CD20+, CD10+, CD5-, slg + (clonal)

10

Viruses associated with Diffuse Large B cell lymphoma

KSHV, HHV8, EBV