Flashcards in Hemostasis Testing and Markers of Pathology Deck (13)
Platelet Count normal range is 150,000 to 450,000. traumatic bleeding levels @ and spontaneous bleeding @
traumatic bleeding: 50,000 (surgeries etc)
spontaneous bleeding: 20,000 (no injury, mucous membranes, organs)
Causes of Thrombocytopenia
Not making enough (aplastic anemia)
Destroying more (immune thrombocytopenia purpura)
Splenic Sequestration (cirrhosis usually around 150,000)
Bleeding time types
Manual bleeding time measures what process of clot formation
platelet plug formation
Automated bleeding time measures platelet
platelet adhesion, 95% sensitive for vWF disease
Prothrombin Time is achieved by adding what to plasma?
Tissue Factor (thromboplastin)
Abnormal PTT could be due to defects in extrinsic and common pathways, and could be due to
Vit K deficiency
Warfarin (blocks Vit K epoxide reductase)
PTT is measured but is dependent on the ISI particular to certain labs. To account for this difference, the____is an equation that normalizes the PTT w/ ISI values
Partial Thromboplastin Time doesn't add what to the plasma?
Thromboplastin (Tissue factor)
Thrombin Time usually around 15 seconds, used to measure any defects in what conversion?
Fibrinogen to fibrin
Best test to screen for dysfibrinogenemia?
Thrombin time because it measures fibrinogen to fibrin time
what test is used to screen for DIC but has low sensitivity for detecting inherited disorders of increased fibrinolysis