Hemostasis Testing and Markers of Pathology Flashcards Preview

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Flashcards in Hemostasis Testing and Markers of Pathology Deck (13)
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1

Platelet Count normal range is 150,000 to 450,000. traumatic bleeding levels @ and spontaneous bleeding @

traumatic bleeding: 50,000 (surgeries etc)

spontaneous bleeding: 20,000 (no injury, mucous membranes, organs)

2

Causes of Thrombocytopenia

Not making enough (aplastic anemia)

Destroying more (immune thrombocytopenia purpura)

Splenic Sequestration (cirrhosis usually around 150,000)

Hemodilution (Trauma)

3

Bleeding time types

Manual
Automated

4

Manual bleeding time measures what process of clot formation

platelet plug formation

5

Automated bleeding time measures platelet

platelet adhesion, 95% sensitive for vWF disease

6

Prothrombin Time is achieved by adding what to plasma?

Tissue Factor (thromboplastin)
Phospholipid
Calcium

7

Abnormal PTT could be due to defects in extrinsic and common pathways, and could be due to

Liver disease
Vit K deficiency
Warfarin (blocks Vit K epoxide reductase)

8

PTT is measured but is dependent on the ISI particular to certain labs. To account for this difference, the____is an equation that normalizes the PTT w/ ISI values

INR

9

Partial Thromboplastin Time doesn't add what to the plasma?

Thromboplastin (Tissue factor)

10

Thrombin Time usually around 15 seconds, used to measure any defects in what conversion?

Fibrinogen to fibrin

11

Best test to screen for dysfibrinogenemia?

Thrombin time because it measures fibrinogen to fibrin time

12

what test is used to screen for DIC but has low sensitivity for detecting inherited disorders of increased fibrinolysis

d-dimer

13

What process of coagulation does d-dimer measure?

fibrinolysis