Mature B cell Neoplasms: CLL/SLL Flashcards Preview

Blood and Lymph > Mature B cell Neoplasms: CLL/SLL > Flashcards

Flashcards in Mature B cell Neoplasms: CLL/SLL Deck (10)
Loading flashcards...
1
Q

Characteristic lab findings w/ CLL

A

Autoimmune hemolytic anemia: warm autoimmune hemolytic anemia
Hypogammaglobulenemia
Paraprotein IgM

2
Q

Classes blood smear findings for CLL

A

Lymphocytosis and Smudge cells

3
Q

Smudge cells seen w/

A

CLL/SLL

4
Q

Diffuse infiltrate of small, round lymphocytes that are CD19+, CD20+, CD5+, CD10-, slg + (clonal)

A

CLL/SLL

5
Q

Weird CD marker associated w/CLL

A

CD5+

6
Q

Genetic categories of CLL w/ 3 year survival (poor prognosis)

A

Unmutated: Ig gene rearrangement but no somatic mutation

7
Q

Genetic categories of CLL w/ >7 year survival (intermediate prognosis)

A

Ig gene rearranged and somatic hypermutation in IgVh

8
Q

Genetic categories of CLL associated w/ trisomy 12

A

13q deletion, 11q deletion, 17p deletion

9
Q

Transformation of CLL that happens 5-10% of the time and leads to large cell lymphoma, increased LAD, and mean survival of less than 1 year

A

Richter Transformation

10
Q

Treatment for rapidly progressing CLL

A

Fludarabine: a purine antagonist

phosphorylated inside the cell, inhibits ribonucleotide reductase and induces apoptosis