Mature B cell Neoplasms: CLL/SLL Flashcards Preview

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Flashcards in Mature B cell Neoplasms: CLL/SLL Deck (10)
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1

Characteristic lab findings w/ CLL

Autoimmune hemolytic anemia: warm autoimmune hemolytic anemia
Hypogammaglobulenemia
Paraprotein IgM

2

Classes blood smear findings for CLL

Lymphocytosis and Smudge cells

3

Smudge cells seen w/

CLL/SLL

4

Diffuse infiltrate of small, round lymphocytes that are CD19+, CD20+, CD5+, CD10-, slg + (clonal)

CLL/SLL

5

Weird CD marker associated w/CLL

CD5+

6

Genetic categories of CLL w/ 3 year survival (poor prognosis)

Unmutated: Ig gene rearrangement but no somatic mutation

7

Genetic categories of CLL w/ >7 year survival (intermediate prognosis)

Ig gene rearranged and somatic hypermutation in IgVh

8

Genetic categories of CLL associated w/ trisomy 12

13q deletion, 11q deletion, 17p deletion

9

Transformation of CLL that happens 5-10% of the time and leads to large cell lymphoma, increased LAD, and mean survival of less than 1 year

Richter Transformation

10

Treatment for rapidly progressing CLL

Fludarabine: a purine antagonist
phosphorylated inside the cell, inhibits ribonucleotide reductase and induces apoptosis