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Flashcards in Targeted Therapies Deck (16)
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1

Non specific biologic agents against cancer (not specific to that particular cancer)

Interferons
Cytokines (Interleukin)

2

Passive Adaptive Biologic Agents (fairly specific)

Immunoglobulins
Monoclonal Antibodies (Mabs)

3

Active Adaptive Bio agents (

Tumor Vaccine: CAR-T

4

Cellular Therapeutics

Modified T Cells

5

Interferons used for

Mycosis Fungoides
Used to be used for: CML, Hair Cell Leukemia, Follicular lymphoma

6

Interleukins and Interferons side effects

fever, myalgias

7

Interleukins used for

IL-2: Renal Cell Carcinoma
Treatment of GVHD

8

Monoclonal Antibody treatment types

Naked example Rituximab

Radioimmuno therapy (seeks out antigen and releases radiation internally)

ADC (Antibody drug conjugate: endocytosed and releases the drug within the cell)

9

**HY**Rituximab used for

B cell lymphoma
CLL
CD20+ ALL
Auto-immune disorders like RA, Lupus, ITP, TTP

10

What must you screen for before administering Rituximab?

Viral reactivation: Hep BV, PML which is a reactivation of the JC virus (polyoma family DNA), Late infections

11

Broad Anti-CD52 Mab

Alemtuzumab, risk of late viral activation

12

Abatacept commonly used for

RA, promotes immune tolerance and anergy

13

Reed Sternberg cells seen in Classical Hodgkin Lymphoma genetic amplification upregulates what immune suppressive molecule that allows it to evade the immune system?

PD-1

14

BiTEs used for

B cell ALL

15

BiTEs used for

B cell ALL

16

CAR-T used for relapsed Hodgkins disease is an example of

Antibody drug conjugate