clinical: Stem cell transplantation Flashcards Preview

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Flashcards in clinical: Stem cell transplantation Deck (19)
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1

Types of transplant

Syngeneic: from twins
Autologous: from patient
Allogeneic: from a match
Xenogeneic: from different species

2

4 reasons for bone marrow transplant

Replace abnormal bt nonmalignant lymphohem system from a normal donor

Ablate to treat a malignancy

Immunotherapy

Gene Therapy

3

Process for both Allogeneic and Autologous

Chemo-radio therapy
Pancytopenic Stage
Engraftment

4

Difference in preservation between autologous and allogeneic

Autologous is cryopreserved whereas Allogeneic is preferred fresh not frozen

5

Drug used for conditioning to eradicate hyperplastic host hematopoesis

Cyclophosphamide

6

Indications from Stem cell transplant

Non-hodgkins lymphoma included relapsed diffuse large b cell lymphoma

Multiple myeloma (FIRST LINE AND IMPROVES SURVIVAL)

7

Allogeneic stem cell transplant indications

Intermediate or High risk AML

Ph+ ALL in adults less than 60

CML (not first line)

Refractory Non-hodgkins leukemia

Aplastic Anemia: for less than 20 yo, sibling match 20-40

Non-malignant Disease: thalassemias and sickle cell

Severe Myeloproliferative Disorders: younger and with match

Myeloproliferative Syndrome advanced disease w/ matched donor and transplant eligible

8

What Non malignant disease can be treated with allogeneic stem cells

Thalassemias and Sickle Cell

9

Low grade lymphomas

Follicular Lymphoma
CLL/SLL

10

Aggressive Lymphomas

Diffuse large b cell lymphoma

Mantle Cell Lymphoma

11

Highly aggressive Lymphoma

Burkitt's Lymphoma

Lymphoblastic Lymphoma

12

Acute Myeloid Leukemia good Cytogenetics

t(15;17)
t(8;21)
Inversion 16
FLT3-; NPM1+

FLT3-;NPM1-; CEPBA double mutant

13

Acute Myeloid Leukemia Intermeduate Cytogenetics

Normal
Trisomy 8
Trisomy 21

14

High risk Cytogenetics for Acute Myeloid Leukemia

-5, -7, 11q23

FLT3+

Complex

Secondary AML or t-AML, MDS-AML

15

Philadelphia + ALL is a definitive indication for

stem cell transplant in CR1

16

Some viral complications for Stem cell transplants

CMV
Adeno virus w/ EBV
(presents w jaundice, elevated AST and ALT and viral PCR+)

17

Acute graft versus host disease can present w/ what sort of rash and where?

Maculopapular Rash on the trunk, neck and palms, also presents w/ diarrhea

18

Most common cause of mortality after transplantaion

Infection

19

Common fungal infections in bone marrow stem cell transplant patients

Candida
Aspergillus
Mucor