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Flashcards in DLA 29 Deck (4)
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1

6- mercaptopurine is used for what?

used to treat some forms of leukemia

2

what does the enzyme Thiopurine methyltransferase do?

this enzyme catalyzes the reaction of mercaptopurine to an inactivated form by methylation

3

what are some functions of mercaptopurine?

6-mercaptopurine functions by inhibition of the purine biosynthetic pathway which are needed for the formation of nucleotides, and thus production of DNA, and RNA.

In this way, 6-mercaptopurine slows proliferation

4

Thiopurine S-methyltransferase Polymorphism?

The dose of mercaptopurine must be reduced in these patients

increased risk for myelosupression when treated with standard doses of thiopurine drugs