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Flashcards in Lecture 50 Deck (3)
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1

What amino acid is changed in hemoglobin to result in a sickle shape?

glutamate is changed to a valine

creates hydrophobic pocket

2

How to test for sickle cell?

1. hemoglobin electrophoresis (HbS moves slower)

2. ASO test

3

What is the mutation difference between DMD and BMD?

DMD= frameshift mutation

BMD: in-frame mutation