Flashcards in Aging & Frailty Deck (24)
Rectangularisation of survival curves means?
Robert Butler coined term:
Cellular senescence is?
cells lose ability to divide
what causes cellular senescence?
DNA damage, Telomeres, apotosis
older people have decreased what to respond to challenges?
How is homeostasis in elderly person?
harder to maintain
what is successful ageing?
changes due only to the aging process and not disease or other factors
what is usual ageing?
combined effects of aging and disease and environment/lifestyle
Frailty is diminished ability to do what?
carry out ADLs
Frailty and stress?
harder to respond, reduced capacity, easier to unbalance
Frailty as a clinical syndrome?
low-grade inflammatory response
What biomarkers is frailty associated with?
IL-6 and TNFa, C-reactive protein
IL-6 is predictive of?
functional decline/muscle mass
what is sarcopenia?
decreased muscle mass due to altered CNS/PNS, hormones, cytokines, disuse
when does skeletal muscle mass start to decline?
what muscle type loses faster?
Type 2 > Type 1
What is Fried's Frailty Criteria? 5
1. unintentional weight loss
4. slow walking speed
5. low physical activity
>2 chronic diseases
Disability is defined as?
physical or mental impairment that limits >1 major ADL
high vulnerability to adverse health outcomes
Co-morbidity health care implications?
harder to coordinate, polypharmacy, fragmentaion
medical syndrome is?
grouping of multiple symptoms to have single dx or disease
geriatric syndrome is?
accumulated effect of impairments in multiple domains = adverse outcome
multiple morbid processes