Flashcards in Chemical Transmission CNS Deck (24)
3 CNS efferent
2 types of sensory afferent?
name the NT and receptor type for sympathetic system
Noradrenaline - A/B (Ligand -gated) adrenoreceptors
name the NT and receptor type for parasympathetic system
ACh: muscarinic receptors(GPCR)
Inactivation usually occurs how with NA and ACh?
2 kinds of receptors at synapse
what causes release of NTs?
4 ways NA is inactivated:
1. pre neuronal uptake: primary
2. prejunctional -ve feedback
3. postjunctional extraneuronal uptake
4. Metabolism via MAO
Cocaine dose response of S. american indians vs western society
what does amphetamines and ephedrine do in the synapse?
displaces NA from storage vesicles even at low levels of neuronal activation
what does cocaine do in the synapse?
prevent NA reuptake
3 'other' classes of NTs?
Amino Acids (GABA, glutamate)
Peptides (opioids, NPY, CCK)
Dopamine is precursor to what?
4 big functions of Dopamine:
cocaine block 3 NT uptake:
why do you get dependence in cocaine?
what does cocaine block at higher levels?
To manage Parkinson's you need to treat with what?
L-DOPA + peripheral DDC inhibitor
dopamine receptor agonist
muscarinic receptor antagonists
to treat Huntington's:
GABA against Baclofen
Can a synapse be both excitatory and inhibitory?
Nope, one or the other
Can a NT be both excitatory and inhibitory?
yes depends on receptor
2 kinds of receptors in CNS:
Ligand-gated: nicotinic/GABA A
GPCR: muscarinic, A/B adrenoceptors
supporting cells of CNS secrete what? role in disease?
degenerative diseases may be loss of these supporting cells