Flashcards in Development of Nervous System Deck (37)
ectoderm becomes what during neuralation?
neural plate, from it: neural crest: from it: neural groove
How many pairs of nerves in CNS?
gradient of formation of nervous system?
rostral to caudal
closing events of neural fold and problems: explain
separate events, risk of one not closing:
eg. spina bifida and ancephaly
what are the 3 distinct vesicles at the rostral end of the neural tube?
prosencephalon splits into?
rhombencephalon splits into?
rhombencephalon splits into two others?
where to retinae come from?
optic vesicles of the diencephalon
thalamus and hypothalamus
What happens to neural crest cells posterior to newly formed neural tube?
migrate away, form lots of structures
Neural crest cells become 4 big things:
muscle, bones of face/jaw
what 4 things does the neural crest form in the PNS?
dorsal root ganglia
symp and parasymp ganglia
migration of neural crest cells are recovered in what pathological processes?
how this is the neuroepithelium?
single cell thic
what is the ventricular zone?
where neural stem cells start, grow inside-out
Stem cells definition?
self-renewing, undifferentiated totipotent: daughter cells able to differentiate
what is radial ganglia?
process that guides a migrating neuron
What is Reelin mutation?
single protein mutation, malformed cortax
what is Lissencephaly? (DCX?)
very few neurons in brain
Fragile X causes commonly?
2 devepmental neural disorders?
somites do what?
develop muscle and bone
neurons controlling distal muscles are medial or lateral?
what does sonic hedgehog do?
induces the floorplate of neural tube to signal 'anterior'
what does the floor plate of the notochord do?
induces ventral horn motor neurons
explain induction of interneurons
appear just dorsal to motor neurons in notochord
do new neurons have axons?
not really, grows out to meet target
how is the initial scaffold of axon tracts laid down?
single pioneering axon