Flashcards in Drug Dependence/Antidepressants Deck (25)
what is drug dependence
compulsive taking of drug
what is drug abuse?
illicit substance use
illicit use of legal substances
recurrent use/adverse consequences
what is habituation/adaptation in drug abuse?
rely on drug to avoid negative symptoms of withdrawal
reward pathways involve what NT system? where?
dopimanergic in nucleus accumbens
Amphetamines displace NA from vesicles and also 2 other NTs? which is it better at releasing?
better at releasing these two than NA
MDMA releases what? what does it do?
MDMA is tweaked version of what drug?
what happens the next time you take LSD?
need higher dose
cross-tolerance with other psychotomimetics
LSD activates what on 5-HT neurons?
autoreceptors in Raphe
Caffeine drug class?
Caffeine blocks what?
Alcohol can cause what at higher doses? does what to CNS?
is a depressant
Alcohol inhibits what receptors? enhances what?
inhibits glutamate: NMDA
what is abstinence syndrome?
eg. ethanol, feel so bad coming off, you just stay on
D9-THC is what? causes?
relaxation: no aggression
sharpened sensory awareness
D9-THC attaches to what receptors?
2 kinds of cannabinoid receptors:
antidepressants:1st, 2nd, 3rd generation?
1st: tricyclic/MAO inhibitors
Tricyclics did what? what was bad?
inhibit reuptake of NA and serotonin
disadvantage of tricyclics
1. week to develop
2. narrow therapeutic window
3. gradual accumulation of side effects
MAO inhibitors did what?
increase 5-HT, NA, DA
What is the cheese reaction for MAO inhibitors?
in irreverisble MAOs: tyramine = hypertensive crisis
Reversible MAO inhibitors were better why?
less cheese reaction
SSRIs did what? why was is good?
inhibit only serotonin reuptake
large therapeutic window