Flashcards in Pathogenesis of Dementia Deck (19)
Neuro degen diseases associated with?
abnormal protein conformations
Alzheimer's genetic risk found on which chromosome?
chromosome 21 (APP mutations)
Alzheimer's risk ____ with each decade after 50?
4 types of Alzheimer's disease?
1. amnestic (temporal)
2. visuospatial (R>L)
3. aphasic (L>R)
what happens to aberrant Abeta monomers?
aggregate to become Amyloid Plaques + inflammation = neuron death
Where do the Abeta monomers/oligomers aggregate?
extra/intra synaptic sites and surfaces of neurons
what is the metal-protein attenuating compound targeting in Alzheimer's?
how to scan for Abeta plaques?
inject carbon 11-PIB to stick to amyloids and PET scan
Alzheimer's on average takes how long to cause death?
spongiform encephalopathy causes death in how long?
CJD is an infectious?
CJD causes what in the brain?
fluid filled holes in the brain
what is PrPc and PrPres?
PrPres is resistant to degradation and insoluble
polymorphism where will determine susceptibility to PrPres?
M129 aka Methionine 129
vCJD into lymph nodes, implications?
circulating in blood stream, risk of blood transmission
incubation period for vCJD in blood?
Parkinson's protein misfold?