Pathogenesis of Dementia Flashcards Preview

Jason's Neuro Block > Pathogenesis of Dementia > Flashcards

Flashcards in Pathogenesis of Dementia Deck (19)
Loading flashcards...
1
Q

Neuro degen diseases associated with?

A

abnormal protein conformations

2
Q

Alzheimer’s genetic risk found on which chromosome?

A

chromosome 21 (APP mutations)

3
Q

Alzheimer’s risk ____ with each decade after 50?

A

doubles

4
Q

4 types of Alzheimer’s disease?

A
  1. amnestic (temporal)
  2. visuospatial (R>L)
  3. aphasic (L>R)
  4. frontal
5
Q

what happens to aberrant Abeta monomers?

A

aggregate to become Amyloid Plaques + inflammation = neuron death

6
Q

Where do the Abeta monomers/oligomers aggregate?

A

extra/intra synaptic sites and surfaces of neurons

7
Q

what is the metal-protein attenuating compound targeting in Alzheimer’s?

A

Abeta oligomers

8
Q

how to scan for Abeta plaques?

A

inject carbon 11-PIB to stick to amyloids and PET scan

9
Q

Alzheimer’s on average takes how long to cause death?

A

30 years

10
Q

spongiform encephalopathy causes death in how long?

A

6 months!

11
Q

CJD odds?

A

1:1000 000

12
Q

CJD is an infectious?

A

protein

13
Q

CJD causes what in the brain?

A

fluid filled holes in the brain

14
Q

what is PrPc and PrPres?

A

PrPres is resistant to degradation and insoluble

15
Q

polymorphism where will determine susceptibility to PrPres?

A

M129 aka Methionine 129

16
Q

vCJD into lymph nodes, implications?

A

circulating in blood stream, risk of blood transmission

17
Q

incubation period for vCJD in blood?

A

6-15 years

18
Q

Parkinson’s protein misfold?

A

a-synuclein

19
Q

Parkinson’s a-synuclein leads to formation of what?

A

Lewy Bodies