3.5 Epigenetics Flashcards Preview

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Flashcards in 3.5 Epigenetics Deck (7)
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1

Define epigenetics

Heritable change in phenotype that doesnt change the DNA sequence

2

What does methylation of DNA do?

Gene repression by methylation in CpG islands

3

What does acetylation of histones do?

Gene activity, open chromatin

4

What is thrifty phenotype theory?

When environmental conditions are bad for the parent, that the environment is likely to be poor for the offspring also.

5

What is meant by a histone code

Suggests that the transcription of genetic info encoded in DNA is in part regulated by chemical modification to histone proteins, in their unstructured ends.

6

What chromatin modifying enzymes switch off the gene?

HDAC and HMT

7

What chromatin modifying enzymes switch the gene on?

HAT, SWI and SNF