3.7 Cancer Genetics Flashcards Preview

COB Genetics > 3.7 Cancer Genetics > Flashcards

Flashcards in 3.7 Cancer Genetics Deck (7)
Loading flashcards...
1

Define Benign

remains localized

2

Define Malignant

invades other tissues

3

Define Metastasis

tumor cells induce secondary tumors

4

Define Oncogenes

mutated, dominant-acting stimulatory genes that cause cancer.

5

Define Tumor suppressor genes

Mutated recessive acting inhibitor genes that are inactive

6

What is the singular key event in cancer progression

Genomic instability

7

Explain dif roles of tumor suppressor genes and oncogenes in cancer initiation and progression

Proto oncogenes normally produce factors that stimulate cell division while tumor suppressor genes inhibit cell division. Oncogenes need a single hit to be activated but tumor suppressors need a double hit to be inactivated.