Flashcards in 2.5 Fatty Acid Oxidation & Ketogenesis Deck (23)
Why is lipid an effective energy storage molecule
Yield of Acetyl CoA, NADH and FADH2 are much larger than what glucose can yield
Fatty Oxidation is favored by what type of insulin/glucagon ratio?
Favored by a low Insulin/Glucagon ratio
What hormones activate TAG degradation by lipase?
Glucagon and Epinephrine
What enzyme adds a CoA on to a FFA after the FA has diffused across the cell?
Fatty Acid-CoA Synthetase
What does CPT1 do?
It catalyzes the reaction of FA-CoA to Acyl-carnitine so that the FA can get through the mitochondrial membrane
How does Acyl-Carnitine diffuse across the mitochondrial membrane?
Through CAT, an antiporter that transports Carnitine back and Acyl-Carnitine in
What does CPT2 do?
It reconverts Acyl-Carnitine back to FA-CoA within the mitochondrial matrix
What inhibits CPT1?
Malonyl CoA. A substrate for Fat synthesis
Where is B oxidation found?
In the mitochondrial cells of the liver
How does insulin, glucagon and energy levels regulate B oxidation?
INCREASE IN ACTIVITY
Low Energy levels
What are the four reactions found in B oxidation
Oxidation --> Hydration --> Oxidation --> Thiolysis
What is the first step in B oxidation and what is released during this reaction?
Oxidation --> FADH2
What is the third step of B oxidation and what is released?
Oxidation --> NADH
What is the last step of b oxidation?
Thiolysis --> Addition of CoA
One pass of Beta Oxidation yields?
1 Acetyl CoA, 1 NADH and 1FADH2
What is the role of peroxisomes in B oxidation
It degrades Very long chain fatty acids
How is B oxidation different in Peroxisomes than in B oxidation
No NADH or FADH2
What are the final products of B oxidation in the Peroxisome
Octanoyl CoA and Acetyl CoA
During odd-numbered B oxidation, what is the fragment remaining that needs to be degraded?
Propionyl-CoA, A 3 carbon fragment
What is the intermediate during odd numbered B oxidation of FA
Propionyl-CoA --> Methylmalony COA --> Succinyl CoA
What enzyme converts Propionyl-CoA to Methylmalonyl CoA in odd numbered B Oxidation
Propionyl CoA Carboxylase
What enzyme catalyzes reaction of Methylmalony CoA to Succinyl CoA
Methylmalonyl CoA Mutase