Flashcards in 2.4 Lipoproteins and Lipid transport Deck (20)
What major tissue and organ destination does Chylomicron have?
Give up FFA to Adipose tissue, muscle and heart
Which molecule of lipid transport has the highest amount of TAGs as in weight?
Which lipid transport molecule has the highest % of cholesterols contained in it
Which molecule has the lowest density based on low protein/lipid ration
Chylomicrons --> VLDL --> IDL --> LDL
What is HDL's target tissue?
What two apolipoproteins do chylomicrons receive as they move to deliver their FFA?
Apo C-II and Apo E from HDL
Name the 5 things that make up the composition of Chylomicrons?
About what percentage of TAGs in Chylomicrons are delivered to the peripheral tissues and liver?
80% to muscle, heart and adipose
20% to liver
Composition of Chylomicron Remnant
TAGs (90% removed so very little)
Is there a difference between the TAGs in Chylomicrons and VLDL?
Chylomicrons contain dietary TAGs
VLDL contains TAGs synthesized from the liver from carbs
Composition of VLDL
Synthesized TAGs (from liver)
Function of Apo C-II
To activate lipoprotein lipase and release FA from TAGs to adipose and muscle.
Does IDL contain Apo C-II and Apo E
Yes, it has not released them yet
Composition of LDL
Function of Apo B-100
To be used as a ligand to recognize LDL receptors on the liver
What type of fats block LDL receptors on the liver and prevent LDL from being endocytosed?
What happens when LDL returns to the liver and returns the cholesterol? What enzyme is affected?
There is an oversupply of cholesterol in the liver.
HMG CoA Reductase is down regulated and turns off cholesterol synthesis. This also down regulates LDL Receptor synthesis
What is the effect of Saturated fats blocking LDL receptors
Increased Cholesterol serum levels
Increases Cholesterol synthesis because HMG CoA Reductase is active with the small amount of cholesterol in the liver
Function of Apo E
Used on Chylomicrons to bind to liver receptors to become enocytosed