Flashcards in 1.3 Cell signalling Deck (12)
Name the 4 approaches to cell signaling
1. Endocrine signaling
2. Paracrine signaling
3. Autocrine signaling
4. Plasma membrane-attached proteins
Define endocrine signaling
Hormone secretion into blood by endocrine gland
Define Paracrine signaling
Secretory cell signaling to adjacent target cell
What type of signaling has target sites on the same cell?
What is bound to the inactivated G-protein subunit before it binds to the receptor
An activated receptor causes conformation change in G-protein triggering what action?
The dissociation of GDP
What finally activates the G-protein after it has been bound to the receptor
G-protein binds GTP and becomes activated
What enzyme catalyzes the conversion of ATP into cAMP
What causes the dissociation of G-protein from Adenylate Cyclase
Hydrolysis of GTP to GDP
cAMP activates what?
Protein Kinase A
What are the two actions of Protein Kinase A
1. Phosphorylates Serine & Threonine residues in many targets to alter their activity
2. Stimulates expression of CREB