Flashcards in 2.11 Methyl transport Deck (29)
The three things that make up the structure of Folic Acid
A lack of what vitamin is the most common vitamin deficiency in the world
Outline briefly how Folic Acid is turned into Tetrahydrofolate
Folic Acid --> Dihydrofolate
Dihydrofolate --> Tetrahydrofolate
What enzyme catalyzes the two reactions that takes folic acid to tetrahydrofolate
How does Tetrahydrofolate differ from Folic Acid
It contains two extra hydrogens on the amino groups
What is the function Methotrexate?
It is a structural analogue of dihydrofolate
Is used as an inhibitor of Dihydrofolate Reductase
What is the role of Tetrahydrofolate and S-adenosyl methionine in the cell?
It carries methyl groups
How does Tetrahydrofolate differ from SAM in its function?
SAM is main carrier of Methyl groups
Tetrahydrofolate carries oxidized version of Methyl like Methylene
Name the five versions of one carbon groups that Tetrahydrofolate carries?
What conversion is the major source of a carbon to be moved?
Serine to Glycine
T or F, Different forms of tetrahydrofolate are interconvertible
How is SAM formed?
Methionine + ATP --> SAM
What enzyme catalyzes the conversion of Methionine to SAM?
Methionine Adenosyl Transferase
How is Methionine formed
Methyl group + Homocysteine = Methionine
What enzyme catalyzes reaction that makes methionine?
What is the coenzyme with Methionine Synthase?
What is the rate limiting step in the activated methyl cycle
Methylene FH4 --> Methyl FH4
What enzyme catalyzes the rate-limiting step of the activated methyl cycle
Methylene Tetrahydrofolate Reductase
What is the Transulfuration pathway
When homocysteine is converted to cysteine
Alanine is made from an amino acid and what other molecule?
Oxaloacetate + Amino acid = ?
Glutamate is formed from an amino acid and what other molecule?
What enzyme catalyzes reaction of glutamate to glutamine
Serine + Homocysteine --> ?
Formation of cysteine from homocysteine is dependent on what?
Dependent on Methionine, an essential AA
Tyrosine is formed from what AA?
WHat enzyme catalyzes the formation of Tyrosine from another AA
What is the underlying issue behind the PKU disorder
Inability to convert Phenylalanine to Tyrosine. Phenylalanine accumulates and inhibits brain development