2016. Novak Et Al. Concise Review: Stem Cell Interevention For People With CP Flashcards Preview

Neuroplasticity > 2016. Novak Et Al. Concise Review: Stem Cell Interevention For People With CP > Flashcards

Flashcards in 2016. Novak Et Al. Concise Review: Stem Cell Interevention For People With CP Deck (5)
Loading flashcards...
1

What overall impact do stem cells seem to induce for patents with CP?

(Novak et al. 2016)

Short term improvements in motor skills

2

Why did stem cell scientists and CP experts unanimously advise that cell replacement therapists might be particularly effective?

(Novak et al 2018)

1. Because the brain damage is often regionally restricted, non progressive and appears limited to few cell types

2. CP involved demyelination Whw-Wge process common to other diagnosis already pioneering stem cell research

3

List three mechanisms by which stem cells might treat CP?

(Novak et al 2016)

1. Regenerative mechanisms: Replacement and/or rep are of damaged brain cells, which may or may not include differentiation

2. Anti-inflammatory mechanisms
-A reduction int he release of excitetoxins, cytotoxic, and oxygen free radicals
-If used early enough might evoke a protective response- that reduces the size and extent of the white matter injruy

3. Trophies mechanisms
-To promote cell survival
-Induce endogenous cell migration, proliferation and differentiation

4

What has hampered scope for patient-based clinical trials for CP?

(Novak et al 2016)

Lack of valid animal model for such a heterogenous condition

5

What is umbilical cord blood (UCB)?

(Novak et al 2016)

Complex internal environment rich in variety of stem and progenitor cell populations

Decks in Neuroplasticity Class (27):