Flashcards in 2013 Boyd article: Promoting neuroplasticity for motor rehabilitation after stroke considering the effects of aerobic exercise and genetic variation on BDNF Deck (15)
What are two postroke rehabilaition strategies that consider the importance of BDNF from the Boyd 2013 paper:
The use of aerobic exercise to enhance brain function
and the incorporation fo genetic information to individualised therapy
Rehabilitation strategies that optimise BDNF effects on neuroplasticity may be especially effective at what?
Improving motor function post stroke
When utilising BDNF rehabiliation strategies common genetic variants can reduces what?
The secretion of the BDNF protein, so individualised motor rehabilaition strategies are needed
Neuroplasticity defined as:
Ability of the CNS to undergo structural and functional change in response to new experiences
Despite major progress in understanding neuroplasity..
Very few new treatment interventions have resulted from this research
BDNF is a member of what family? And has been identified as a key to mediate what?
Is a member of the neurotrophin family, a group of proteins involved in neuroprotection, neurogenesis and neuroplasticity
and has been identified as a key mediator of motor learning and rehabilation after stroke
Aerobic exercise affects the brain indirectly and directly how?
(Hint- what pathways direct?)
Indirectly through improvements in general health and fitness
Directly through alternations in molecular signally pathways that act directly on the CNS
Is Aerobic exercise the only exercise to have this impact on neuroplasticity?
No, resistance exercise has a growing body of evidence
Evidence shows that exercise induced increases in BDNF benefit what function?
How long are systematic levels of BDNF increased following a bout of aerobic exercise in humans?
Answer: 10-60 minutes
And also shown in one study when used before, or after (Roig)
Question: Is there any more recent evidence on this?
A large meta-analysis of 18 aerobic exercise training interventions studies in older adults concluded that the largest effects on cognition occur on what?
Executive control domain, including functions such as planning, scheduling, working memory, and multi-tasking
Is there any evidence that the benefits of aerobic exercise on brain function persists at follow up if exercise stopped?
Not that the authors are aware of
Does aerobic exercise itself induce neuroplasticity?
No, rather it promotes the development of a neural environment that is supportive of plasticity
Pairing aerobic exercise in close temporal proximality with behavioural training will serve to prime what area for neuroplastic chance?