Jia. 2018. A New Approach To Cerebral Palsy: Discussion Of The Effective Components Of Umbilical Cord Blood And Its Mechanisms Of Action Flashcards Preview

Neuroplasticity > Jia. 2018. A New Approach To Cerebral Palsy: Discussion Of The Effective Components Of Umbilical Cord Blood And Its Mechanisms Of Action > Flashcards

Flashcards in Jia. 2018. A New Approach To Cerebral Palsy: Discussion Of The Effective Components Of Umbilical Cord Blood And Its Mechanisms Of Action Deck (8)
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1

What hope is there of umbilical cord blood for CP (2 big reasons)?

(Jia. 2018)

1. Scientifically plausible tratement

2. Possible cure for CP

2

What can be impact of CP cause in the brain?

Jia, 2018

Hypoplastic brain tissue, resulting in loss of Neuron function

3

What are the different causes of CP? (What 4 things listed)

(Jia, 2018)

Caused by multiple of things including

1. hypoxia inducted brain damage
2. genetic factors
3. mutations
4. And other hypothesis- including therapies of infection/inflammation)

4

What other things do paitients have with CP? (7 things and their % prevalence)


(Jia, 2018)

1. Pain- 75%
2. Intellectual disability 50%
3. Inability to walk 33%
4. Inability to talk 25%
5. Epilepsy 25%
6. Incontinence 25%
7. Blindness 10%

5

There are 6 reasons why umbilical cord blood has advantages over other types of stem cell

(Jia 2018)

1. Treatment safety and efficacy

2. Ethics

3. Non-neoplasticism proliferation

4. Accessibility

5. Ease of preservation

6. Regulation of immune response (based on findings from animal and clinical trials)

6

What are the three aspects of UCB interventions for CP?


(Jia 2018)

1. Homing and neurogeneration

2. Trophies factor degradation

3. Neuroprotective effects

7

In CP animal studies stem cells have shown good results depending on what two factors?

(Jia 2018)

1. Self renewal: the capacity to generate identifiable cells

2. Multipotency: capacity to generate many cell types

8

In animal studies using UCB substantial progress has been shown in three areas:

1. Migration to sites

2. Improvement of functional loss

3. Prevention of white matter damage

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