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1

What makes you more vulnerable to addiction? (4 things)

- age under 25
- underlying conditions
- high pressure jobs
- high-stress environments

2

-decreases levels of dopamine & serotonin
-belongs to amphetamine class of drugs

MDMA/Ecstasy

3

- varies between different receptors
-an attraction to a receptor

affinity

4

- was a controversial study
- showed less brain activity in drug users and those recovering

cocaine w PET scan

5

- direct agonist to dopamine
-use causes permanent changes

cocaine

6

- powerful class of drugs

amphetamine

7

- led to participants committing suicide
-permanent decrease in serotonin levels

Ecstasy study

8

- process of forming neuronal tolerance
-plugs the receptor making it non-functional

"capping" a receptor

9

- decrease in # of available receptors
- must take more drug for the same effect

tolerance

10

- super high levels of activity

color white on the pet scans indicated

11

- is aversive
- goal pathway neurons fire

motivation

12

- pleasure neurotransmitter

dopamine

13

- involved in pleasure, learning, reward
- series of projections from the VTA to other areas of the brain

mesocoricolimbic dopamine pathway

14

- is stimulated by the VTA
- is the area where dopamine is released

nucleus accumbens

15

- is considered a "reward center"
- is connected to the hippocampus, cortex, nucleus accumbens

Ventral Tegmental Area (VTA)

16

The nicotine patch is 45% successful

false (25%)

17

- activate mesolimbic dopamine pathway/nucleus accumbens
-produce dependency
-produce neuronal tolerance

To be addictive something must:

18

- can cause changes in other body tissues
-drug is taken to minimize withdrawal symptoms

dependency

19

- Does not cause long-term changes in brain
-does not activate nucleus accumbens

Why isn't nicotine addictive?

20

- partially antagonizes brain

second hand smoke exposure

21

- binds to nicotinic receptors
-released by cholinergic neurons

acetylcholine

22

The nucleus accumbens does neurogenesis

false