Pharmacology of Airways Disease Flashcards Preview

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Flashcards in Pharmacology of Airways Disease Deck (9)
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1

Which drugs can inhibit the bronchospasm in the immediate/early phase of asthma?

B2 receptor agonists (salbutamol, terbutaline, salmeterol, formoterol)

Anticholinergics (ipratropium, tiotropium)

Methyxanthines (theophylline)

(+ leukotriene receptor antagonists)

BAM

2

Which drugs are used to reverse the inflammation in the late phase of asthma?

Glucocorticoids:

  • Beclomethasone
  • Fluticasone
  • Prednisolone
  • Hydrocortisone

Leukotriene receptor antagonists

LuGlu

3

What are the 3 main systems to target in obstructive airways disease?

Bronchiolar smooth muscle constriction (nervous system control)

Airway hyper-responsiveness (acute immune response)

Airway chronic inflammation (target immune system in the lung)

4

What is used for the management of severe acute asthma?

O: Oxygen
S​: Salbutamol (B2 agonists)
H: Hydrocortisone (glucocorticoid)
I: Iptraropium (anticholinergic)
​T: Theophylline (methyxanthine)

5

What are the effects of the sympathetic and parasympathetic nervous systems on bronchiolar smooth muscle?

Sympathetic: bronchodilation

Parasympathetic: bronchoconstriction

6

Which receptor do anticholinergics act on to reduce smooth muscle constriction?

Which neurotransmitter do they block at this receptor?

Muscarinic (M3) receptors

Block the binding of ACh 

7

Which intracellular substance do methylxanthines act on?

Inhibit phosphodiasterase enzymes preventing the breakdown of cAMP

8

Which immune cells in the lungs do glucocorticoids target?

  • T-lymphocytes
  • Macrophages
  • Eosinophils

9