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Flashcards in Endocrine Drugs Deck (111)
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1

Why is Propylthiouracil (PTU) less frequently used in treatment for hyperthyroidsim in cats

Higher incidence of serious side effects

2

What is the best way to dose large patients (>50lbs) for Levothyroxine?

mg/m2

________________________

To avoid oversupplementation

3

General targets of drug therapy for "hyper" endocrine diseases 

Destroy abnormal tissue/ get rid of the source

Inhibit production of the substance

Enhance elimination of the substance

Inhibit function of the substance

4

Commonly used long acting insulins

Glargine

Prozinc (PZI)

Detemir

5

Clinical signs of Acute Hypocalcemia

Hyperesthesia/ pawing at the face

Tremors progressing to flaccid paralysis, seizures, hyperthermia, bradycardia

6

Endogenous hormone of glucocorticoids

Cortisol

7

Non genomic effects of glucocorticoids

Glucocorticoid receptors in the membrane → Rapid Effects

8

Short term management of acute hypocalcemia

Parenteral Calcium

Oral Calcium

9

Pharmacokinetics of what type of insulin is generally most predictable

Short-Acting

10

Examples of glucocorticoids with salt ester excipeints

Dexamethasone sodium phosphate- Azium, DexSP

Methylprednisolone sodium succinate - Solu-Medrol

Hydrocortisone sodium phosphate - Solu-Delta-Cortef

11

Treatment of atypical addisons

Prednisone

12

Long term side effects of glucocorticoids

Increased susceptibility to infection

Skin changes - hyperpigmentation, thinning, alopecia

Collagen disease, delayed wound healing

Hypertension, thromboembolic disease

Panting

Addisonian signs

13

14

Oral calcium options for treating Chronic Hypocalcemia

Ca Carbonate

Ca Proprionate

15

Adverse effects of glucocorticoids

PU/PD

Catabolic

Antagonize Insulin

Inhibit fertility

"Stress" leukogram

Impair healing

Calcinosis cutis, osteoporosis, thin skin and alopecia

Increase GI acid and decreased mucus

Increase fat absorption/ deposition

16

Regulation of glucocorticoids

Regulated by the hypotalamus/pituitary through the release of CRH and ACTH

17

Drugs that target the production of ACTH by the pituitary gland

Pergolide- Permax

Selegiline- Anipryl

18

Mechanism of action of mineralcorticoids

Regulate Na retention / K excretion by the kidney

19

T/F: Ca Chloride can be given SQ/IM

False

__________________

Ca Chloride is caustic

20

Primary goal of Diabetes Melitus therapy

Address the insulin deficiency

21

Mechanism of action of oral hypoglycemic agents

Stimulate insulin secretion by the pancreatic beta-cells by blocking K channels

Increase tissue sensitivity to insulin

22

Physiologic effects of glucocorticoids

Increase calcium excretion

Reduce Fever

Suppress immune system

Lymphotoxic

23

Modes of administration for Regular Insulin- Humulin-R

IV

IM

SQ

24

Excipients that may be used for injectible glucocorticoids

Salt Esters

Insoluble Esters

25

Cabimazole is converted to what in the body

Methimazole

26

How does hypoparathyroidism effect calcium

Hypoparathyroidism results in inability of the body to convert vitamin D to calcitriol, thus the GI tract cannot absorb calcium

27

Treatment of typical addisions

Prednisone + either DOCP or Fludrocortisone

28

Most commonly used drug to treat Cushings disease

Trilostain - Vetoryl

29

Commonly used short acting insulin

Regular Insulin - Humulin-R

30

In the cases of "hypo" endocrine diseases we need our therapy to do what

Replace an endogenous substace