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Flashcards in Distribution Deck (18)
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1
Q

“Compartments” Concept

A

Groups of tissues/ fluids for which the rates of update/clearance of a drug are similar; distribution of drugs involves movement between different compartments

2
Q

Factors that affect distribution

A

Physiochemical properties of the drug

Concentration gradient between blood and tissue

Blood flow : tissue mass

Affinity of drug for tissue

3
Q

Body fluids compromise ________ % of body weight

A

57%

4
Q

Intracellular fluid constitutes _________%

A

40%

5
Q

Extracellular fluid constitutes _____%

A

17%

6
Q

Apparent Volume of Distribution

A

Apparent volume necessary to contain the entire amount of a drug if were evenly distributed throughout the body at the concentration present

7
Q

Examples of tissues with high relative blood flow

A

Brain, Heart, Kidney, Endocrine Organs

8
Q

Examples of tissues with low relative blood flow

A

Bone, Fat , inactive muscle

9
Q

Blood Brain Barrier

A

Tight junctions between capillary endothelial cells and glial cells surrounding the pre capillaries force drugs to cross cell membrane to enter, CSF is constantly produced keeping space around the CNS “washed”

10
Q

What mechanisms are responsible for drug efflux out of the CNS?

A

Active Transport mechanisms ___________________________

P-gp

11
Q

Plasma protein binding is an important means of

A

Distribution

12
Q

Acidic drugs bind primarily to

A

Albumin

13
Q

Basic drugs primarily bind to

A

Alpha1-acid glycoproteins, beta-globulins and some others

14
Q

Plasma protein binding is generally (reversible/irreversible)

A

Reversible

15
Q

Bound drug is generally confined to the

A

Blood

16
Q

Bound drug is (active/inactive)

A

Inactive

17
Q

Other factors that affect drug distribution

A

Stereochemistry

Tissue binding

Rate of Metabolism

Rate of Excretion

Redistribution

18
Q

Distribution

A

Transfer of drugs from the bloodstream to tissues around the body