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Flashcards in Introduction (Shokry) Deck (66)
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1

T/F: Drugs can act as antigens or haptens

True

2

Phenoxybenzamine and Epinephrine is an example of _______________ antagonism

Phenoxybenzamine and Epinephrine is an example of noncompetitive pharmacological antagonism

3

Pharmacodynamics involves

Action of drugs

Mechanisms of action

Structure-Activity relationships

4

Factors related to the animal

Species

Breed

Individual

Body Weight

Age

Sex

Temperament

Idiosyncrasy

Hypersensitivity

Disease

Tolerance

5

Adverse effect of captoprin in dogs

Renal disease

6

________ route of administration has a slower onset and longer duration of action.

Oral route of administration has a slower onset and longer duration of action.

7

Factors related to the drug

Route of administration

Timing of administration

Cumulation

Drug- drug interaction

8

Alteration of biotransformation occurs when

Enzyme inducers decrease the effects of other drugs or enzyme inhibitors increase the effect of other drugs

9

Reactive Drug Metabolites (RDM)

Bind to cellular macromolecules resulting in cellular damage and usually involve the immune system

10

Antagonism

Administration of a drug results in decrease in the pharmacological response of another drug

11

Thiopental tolerance when given to an animal under phenobarbital treatment is an example of 

Cross tolerance

12

Phenobarbital is an enzyme (inducer/ihibitor)

Phenobarbital is an enzyme (inducer/ihibitor)

13

Drugs that act as antigens cause hypersensitivity reactions by

Antigen-Antibody reactions

14

Chloramphenicol is an enzyme (inducer/ihibitor)

Chloramphenicol is an enzyme (inducer/ihibitor)

15

Acquired tolerance can occur due to

Enzyme induction

Increased excretion

Down- regulation of receptors

16

Three general factors that modify drug dosage and response

Factors related to the animal

Factors related to the drug

Factors related to the environment

17

Alteration of excretion occurs when

Urinary alkalinizers enhance renal excretion of weak acidic drugs or when urniary acidifiers enhance excretion of weak basic drugs

18

Drug

Any chemical that is capable of altering biological function

19

Fluoroquinolones given to young patients cause

Fluoroquinolones given to young patients cause cartilage damage

20

Tetracyclines given in young patients cause

Tetracyclines given in young patients cause yellow discoloration of teeth

21

Clinical signs of idiosyncratic reactions

Fever, Urticaria, Anaphylaxis, Hematologic and Organ Toxicities

22

Pharmacotherapeutics

Therapeutic uses of the drug

23

Glucocorticoids given to young patients cause

Glucocorticoids given to young patients cause growth inhibition

24

Drugs that act as haptens  cause hypersensitivity reactions by

Interaction with the immune system

25

Idiosyncratic reactions are typically caused by ______________

Idiosyncratic reactions are typically caused by Reactive Drug Metabolites (RDMs)

26

Adverse effect of enrofloxacin in cats

Retinal damage

27

Examples of drugs that act as haptens

Penicillin

Sulfonamides

Aspirin

Morphine

Tubocurarine

28

Collies are sensitive to __________

Collies are sensitive to Ivermectin

29

Types of tolerance

Natural

Acquired

30

Cumulation

Rate of elimination is slower than the rate of absorption