Diabetes Insipidus (DI) Flashcards Preview

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Flashcards in Diabetes Insipidus (DI) Deck (13)
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1
Q

Nephrogenic diabetes insipidus is caused by

A

Impaired responsiveness of the kideny to ADH

2
Q

Chlorpropamide

A

Thiazide Diuretic

Oral hypoglycemic sulfonylurea drug

Restricts sodium chloride intake

Not very effective in the treatment of CDI in cats and dogs

Requires the presence of endogenous ADH to act

3
Q

Central Diabetes Insipidus is treated with

A

Desmopression, DDAVP

Thiazide Diuretics

4
Q

Actions of ADH

A

Stimulate reabsorption of water → increased water in ECF and decreased ECF osmolality

Stimulate the thirst center and increase water intake → increased ECF and decreased ECF osmolality

5
Q

Drug of choice for Central Diabetes Insipidus in dogs and cats

A

Desmopressin, DDAVP

6
Q

Desmopressin, DDAVP

A

Synthetic ADH analog

Minimal vasoconstrictor action

Given parenterally or nasal drops on conjunctival sac

7
Q

Drug of choice for Nephrogenic Diabetes Insipidus

A

Thiazide Diuretics

8
Q

T/F: Natural ADH is more potent and has longer duration of action than Desmopressin, DDAVP

A

False

9
Q

Types of Diabetes Insipidus

A

Central Diabetes Insipidus

Nephrogenic Diabetes Insipidus

10
Q

Central Diabetes Insipidus is caused by

A

ADH deficiency

11
Q

Diabetes insipidus is commonly associated with what clinical manifestations?

A

Polyuria and Polydipsia

12
Q

How is ADH stimulated to be secreted

A
  1. Volume contraction increases ECF osmolality
  2. Increased ECF stimulate osmoreceptors
  3. Osmoreceptors stimulate ADH Secretion

OR

  1. Hypotension stimulate volume receptors
  2. Volume receptors stimulate ADH secretion
13
Q

How is natural ADH used in the diagnosis of Diabetes Insipidus

A

Administered IM or IV over 1 hour in lactated ringers or 5% dextrose solution