Pharmacology - Chapters 101-102 - Anticancer Drugs

Question 1

Cytotoxic Drugs - act directly on…

Answer 1

Cancer cells to cause their death.

Question 2

What are the 6 Cytotoxic Drugs?

Answer 2

Alkylating Agents, Antimetabolites, Antitumor Antibiotics, Mitotic Inhibitors, Topsoisomerase Inhibitors, Miscellaneous Cytotoxic Drugs.

Question 3

Alkylating Agents - cells are killed by…

Answer 3

alkalization of DNA.

Question 4

What are the classes of Alkylating Agents?

Answer 4

Nitrogen Mustards (Cyclophosphamide - Cytoxan), Nitrosoureas (Carmustine - BCMU), and others (Cisplatin - Platinol-AQ) and (Busulfan - Myleran.)

Question 5

What are the 3 types of Antimetabolites?

Answer 5

Folic Acid Analog (Methotrexate - Rheumatrex), Pyrimidine Analogs (Cytarabine - Cytosar-U), and Purine Analogs (Mercaptopurine - Purinethol.)

Question 6

What are some of the anti-tumor antibiotics?

Answer 6

Dactinomycine, Doxorubicin, Daunorubicin, Valrubicin, Bleomycin, Pilcamycin

Question 7

What are the two types of Mitotic Alkaloids?

Answer 7

Vinca Alkaloids (Vicristine, Vinblastine, Vinorelbine) and Taxoids (Paclitaxel, Docetaxel)

Question 8

What are some Topoisomerase Inhibitors?

Answer 8

Topotecan, Irinotecan, and Etoposide

Question 9

What are the two Misc. Cytotoxic Drugs?

Answer 9

Asparaginase and Mitotane