Pharmacology - Chapter 68 - Immunosuppressants

Question 1

Immunosuppressants - inhibit…

Answer 1

immune response.

Question 2

What are immunosuppressants used for?

Answer 2

Prevention of organ rejections and treatment of autoimmune disease.

Question 3

Toxicity - at the doses requires to suppress graft rejection, all of these drugs are ___.

Answer 3

Toxic.

Question 4

Cyclosporine (Sandimmune) - what is it used for?

Answer 4

Prevent rejection of transplants.

Question 5

Cyclosporine (Sandimmune) - Mechanism

Answer 5

To suppress the production of interleukin-2

Question 6

Adverse Effects - Cyclosporine (Sandimmune)

Answer 6

Nephrotoxicity, Infection, Hypertension.

Question 7

Azathioprine (Imuran) - what does it do?

Answer 7

Suppresses cell mediated and humoral immune responses.

Question 8

What is Azathoprine (Imuran) used for?

Answer 8

Adjuvant treatment with transplants/autoimmune disorders.

Question 9

What are some adverse effects of Azathioprine (Imuran) ?

Answer 9

Neutropenia, Thrombocytopenia, Neoplasma.

Question 10

What are monoclonal antibodies?

Answer 10

Antibodies directed against components of the immune system; suppress immune responses.

Question 11

What are monoclonal antibodies used for?

Answer 11

Prevent rejection of transplants.

Question 12

What are some adverse effects of monoclonal antibodies?

Answer 12

Fever, chills, dyspnea, chest pain.