Review Session Extra Info Flashcards Preview

MSI Unit II > Review Session Extra Info > Flashcards

Flashcards in Review Session Extra Info Deck (28)
Loading flashcards...
1

Fas Ligand

Fas ligand is on the surface of CD8+ cells, when it binds to the FAS receptors on infected cells, signals the cell to kill itself (apoptosis)

2

Describe T cell maturation

start in bone marrow

travel to thymus, become CD4 or CD8

travel to lymph, need dendrite to be activated via
1) B7 of dendrite to CD28 of T-cell
2) MHC of dendrite presenting antigen to TCR of Tcell
3) clonal proliferation

3

how does a T-cell interact with a macrophage or B cell?

TCR interacts with the MHC, the CD40ligand interacts with the CD40 receptor on the macrophage/b-cell

4

Describe the B cell and the FDC

B-cell deposits the antigen on the FDC, then becomes activated to proliferate, then the clones with different somatic hypermutation compete for binding to the antigen

5

when T cells get activated

downregulate CD28, upregulate CTLA to bind to the b7

6

lack of CTLA4 will cause

autoimmunity

7

telomerase does what?

extends the parental strand by laying down an RNA template

8

DNA damage response does what?

phosphorylates p53 which then can do the following
1. induce apoptosis
2. activate DNA repair
3. activate p21 which halts the cell cycle by binding CDK's

9

HOT T-Bone stEAK

IL1 - pyrogen, increase heat, cause inflammation, sticky endothelium
IL2 - stimulate T-cells to proliferate (clonal expansion), done on self
IL3 - stimulates bone marrow
IL4 - induce b cells to make IgE, stimulates TH2 differentiation
IL5 - tells b cells to class switch to IgA - stimulate eosinophils

10

IL12

TNF alpha

IFN-gamma

IL10

differentiate to TH1

septic shock mediator

activate macrophages and TH1 differntiation

inhibits activated T-cells, secreted by T-regs

11

Once in thymus, T-cells are classified as

double positive

12

in T-cells, after the alpha chain is successfully rearranged

the gamma is excised, in order to make the alpha, two segments which flank the gamma must be connected.

13

the b7 signal is needed for

activation of naive T-cells and cloncal expansion

14

TH1 is good for

intracellular defenses

stim by IL12 and IFNgamma

makes IL2 and IFN gamma

15

TH2 good for

parasites, extracellular

stim by IL4, makes IL4, 5, 6 for b cells to make IgE

16

CD2

on immature t-cell progenitors double -

17

cd4

located on helper T cells

18

cd8

located on cytotoxic t cells

19

CD28

found on T-cells, allows activation by dendritic b7

20

CD40L

on CD4 cells, activates APC by binding CD40

21

FasL

found on cd8 cells, binds to Fas on cells and induced apoptosis

22

Macrophage receptors

CD40, MHC2, CD14 (special marker, only on macrophages)

23

NKT recetors

what do they do?

alpha/beta receptor

they dont kill, secrete IL4 and IFN-Gamma to stim macrophages and TH1

24

HLA-E presents what to show its not infected?

a self "leader sequence"

25

B cell receptors

cd19, 20, 21, 40, 81, MHC1, MHCII

26

NK cell receptors

CD56, CD16 (recognizes Fc on IgG, stimulating), and CD94 (recognizes HLA-E, inhibitory)

27

MHC1a is recognized by

MHC1b is recognized by

1a = CD8+ t cells

1b = Natural KIller Cells

28

gamma delta recognize, located on?

lipids on CD1d receptor

NKT cells.

Decks in MSI Unit II Class (46):