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Flashcards in Resp Drugs Deck (30)
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1

Side effects of TB drugs

Rifampicin: Orange tears and urine

Isoniazid: Peripheral Neuropathy

Pyrazinamide: Gout and joint pain

Ethambutol: Optic neuritis

All give hepatotoxicity

2

Give examples of SABAs

Salbutamol

3

Side effects of Beta-agonists

Tremors
Tachycardia
Anxiety
Headaches

4

Give examples of Corticosteroids

Beclometasone (inhaled)
Prednisolone (oral)

5

Side effects of ICS

Dysphonia
Oropharyngeal candidiasis

6

Give examples of Muscarinic-antagonists

Short acting: Ipratropium
Long acting: Tiotropium

7

Side effects of Muscarinic-antagonists

Dry mouth
Flu-like cough
Sore throat
Headaches
Backaches
Glaucoma

8

Give examples of Methylxanthines

Theophylline
Aminophylline

9

Side effects of Methylxanthines

Nausea
Vomiting
Abdominal discomfort
Headaches
Convulsions (at toxic levels)

10

Give examples of CysLT Receptor Antagonists

Montelukast

11

Side effects of CysLT Receptor Antagonists

GI disturbances
Headaches
Sleep disturbances

12

Give examples of Mucolytics

Carbocisteine

13

Side effects of Mucolytics

Diarrhoea
Nausea
GI disturbances

14

Give examples of Cromones

Sodium cromoglicate

15

MoA of Cromones

Mast cell inhibitors and stabilisers

16

MoA of Xanthines

- Blocks adenosine receptors
- Competitive inhibitor for phosphodiesterase

17

MoA of Muscarinic-antagonists

Ipratropium- Inhibits M1, M2, and M3 receptors
Tiotropium - Inhibits M3 receptors

18

MoA of CysLT Receptor Antagonists

Blocks the effects of leukotrienes

19

MoA of Corticosteroids

- Reduce mast cells, macrophages, eosinophils and T cells
- Stimulate B2 receptors to a certain extent

20

MoA of H1 Receptor Antagonists

Reduces the effects of histamine released from mast cells

21

Give examples of H1 Receptor Antagonists

Loratidine, fexofenadine, cetirizine

22

Effect of CysLT Receptor Antagonists

Reduce inflammation

23

Effect of Muscarinic-antagonists

- Relax ASM
- Inhibit mucus production

24

Effect of Methylxanthines

- Relax ASM
- Reduce inflammation

25

MoA of Mucolytics

Reduce sputum viscosity

26

Effect of Mucolytics

- Reduce sputum viscosity
- Make sputum easier to cough up
- Reduced COPD exacerbations

27

Effect of Cromones

Reduce inflammation

28

Effect of Corticosteroids

Decrease inflammation

29

MoA of Beta-2-adrenoceptor Agonists

Stimulate B2 receptors

30

Effect of Beta-2-adrenoceptor Agonists

- Relax ASM (bronchodilate)
- Vasodilate
- Reduce inflammation
- Increase mucus clearance