Autonomic Receptors Flashcards Preview

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Flashcards in Autonomic Receptors Deck (57)
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1

What are the two types of autonomic receptors?

Cholinergic and Adrenergic

Cholinergic - stimulated by ACh

Adrenergic - stimulated by noradrenaline and adrenaline

2

What are the types of Cholinergic receptors?

Nicotinic and Muscarinic

3

What are the Nicotinic receptors?

Nn and Nm

4

Where are Nicotinic receptors found?

The Adrenal Medulla

5

What are Cholinergic receptors?

They are stimulated by ACh

6

What are Adrenergic Receptors?

They are stimulated by Noradrenaline and Adrenaline

7

When stimulated what do Nicotinic receptors do?

They increase Na influx into cells

8

Where are Nn receptors found?

At autonomic junctions

9

Where are Nm receptors found?

In muscle

10

What are the Muscarinic receptors?

M1, M2 and M3

11

When stimulated what do Muscarinic receptors do?

They stimulate G proteins

12

What types of G proteins are there?

Gq, Gi and Gs

13

What does Gq do when stimulated?

Increase stimulation of Phospholipase C

14

What does Gi do when stimulated?

Inhibit adenyl cyclase 

Decrease cAMP

15

What does Gs so when stimulated?

Stimulation of adenyl cyclase

Increase cAMP

16

When stimulated, what does M1 do?

- Increased acid secretion in the stomach 

- Increases gland secretion in the ENS

 

17

When stimulated, what does M2 do?

- Decreases HR by increasing SA-AV node delay

18

When stimulated, what does M3 do?

M3 gives a "wet picture" - lots of secretions

- Contraction of visceral smooth muscle (bronchoconstriction) 

- Increased secretion of Saliva 

- Increases Vasodilation


- Pupil constriction

- Relaxed sphincters

- Vomiting/urination etc

19

What are the types of Adrenergic receptors?

Alpha, Beta and Dopamine

20

What are Alpha receptors?

A1 and A2

21

Where are M1 receptors found?

In the ENS and the CNS

22

Where are M2 receptors found?

In Cardiac Muscle

23

Where are A1 receptors found?

In the heart and vascular smooth muscle

24

Where are A2 receptors found?

In some vascular smooth muscle

25

Where are B1 receptors found?

In the heart

26

Where are B2 receptors found?

In respiratory and vascular smooth muscle

27

What is the opposite of the B1 receptor?

The M2 receptor

28

When stimulated, what does A1 do?

- Increases vasoconstriction through contraction of vascular smooth muscle

- Increases HR

- Increases the force of contraction of the heart

- Pupil dilation

- Constricts sphincters

29

When stimulated, what does A2 do?

- Inhibits noradrenaline release

30

When stimulated, what does B1 do?

- Increases the force of contraction of the heart (SV)

- Increases HR by decreasing the SA-AV node delay

- Increases CO (SV X HR)