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Flashcards in Renal Drugs Deck (25)
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1

Name some chemo drugs used in Renal

Cyclophosphamide, IL-2 (Aldesleukin), IFN-Alpha, Sunitinib

2

Name some immunosuppressive drugs used in Renal

Azathioprine, mycophenolate

3

MoA of Azathioprine

Inhibits purine synthesis. Purines are needed to produce DNA and RNA. By inhibiting purine synthesis, less DNA and RNA are produced for the synthesis of white blood cells, thus causing immunosuppression.

4

MoA of Mycophenolate (MMF)

leads to inhibition of DNA replication in T cells and B cells

5

MoA of Hydroxychloroquine

by decreasing TLR signaling, reduces the activation of dendritic cells and the inflammatory process.

6

Name a calcineurin inhibitor

Tacrolimus

7

MoA of

Inhibits calcineurin, thus inhibiting both T-lymphocyte signal transduction and IL-2 transcription. It is immunosuppressive.

8

Name some inotropes

Digoxin, Amiodarone

9

Name a vasopressor

Epinephrine

10

Reason for using inotropes

to restore effective tissue perfusion and to normalize cellular metabolism.

11

MoA of Calcium Resonium

removes excessive amounts of potassium from the blood

12

Name a vasopressin V2 receptor antagonist

Tolvaptan

13

MoA of Tolvaptan

Improves urine flow without causing the body to lose too much sodium as you urinate.

14

MoA of Fabrazyme

Agalsidase beta reduces deposits of globotriaosylceramide (GL-3) in the kidneys

15

MoA of Phenazopyridine

when excreted into the urine, has a local analgesic effect.

16

Side effects of Phenazopyridine

Turns urine orange
Discolours contact lenses

17

Name some Alpha-blockers

Tamulosin, Alfuzosin

18

MoA of Alpha-blockers

When alpha 1 receptors in the bladder neck and the prostate are blocked, this causes a relaxation in smooth muscle and therefore less resistance to urinary flow. Due to this, the pain associated with BPH can be reduced.

19

MoA of Phenylephrine

decongestant that shrinks blood vessels

20

Name a 5α-reductase inhibitor

Finasteride

21

MoA of Finasteride

By inhibiting 5α-reductase, finasteride prevents conversion of testosterone to dihydrotestosterone (DHT) by the type II and III isoenzymes, resulting in a decrease in serum DHT levels by about 65 to 70% and in prostate DHT levels by up to 85 to 90%

22

MoA of Luteinizing hormone releasing hormone agonist/analogue

A gonadotropin-releasing hormone agonist (GnRH agonist) is an analogue that activates the GnRH receptor resulting in increased secretion of FSH and LH

23

MoA of Anti-androgens

they prevent androgens like testosterone and dihydrotestosterone (DHT) from mediating their biological effects in the body. They act by blocking the androgen receptor (AR) and/or inhibiting or suppressing androgen production

24

What is Diethylstilbestrol

a synthetic nonsteroidal estrogen

25

MoA of Flouracil

principally a thymidylate synthase (TS) inhibitor- causing the death of cells which are growing fastest