Flashcards in MSK Drugs Deck (40)
Name some NSAIDs
When to use Etodolac?
symptomatic relief of osteoarthritis and rheumatoid arthritis.
Side Effects of Indometacin?
headache, dizziness, and gastro-intestinal disturbances
When to use Celecoxib?
relief of pain in osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis
MoA of Ibuprofen
It is a propionic acid derivative with anti-inflammatory, analgesic, and antipyretic properties.
MoA of NSAIDS
They reduce the production of prostaglandins by inhibiting the enzyme cyclo-oxygenase.
Why do you need to stay on NSAIDS for a while?
Pain relief starts soon after taking the first dose and a full analgesic effect should normally be obtained within a week, whereas an anti-inflammatory effect may not be achieved (or may not be clinically assessable) for up to 3 weeks.
Why is Naproxen good to use in clinical practice?
because it combines good efficacy with a low incidence of side-effects
When are NSAIDS contraindicated?
GI patients- prescribe in combination with a PPI to protecti GI tract.
Name some Analgesics
Name some Disease Modifying Anti-Rheumatoid Drugs (DMARDS)
MoA of Methotrexate
inhibition of enzymes involved in purine metabolism
MoA of Sulphasalazine
Suppression of IL-1 & TNF-alpha, induce apoptosis of inflammatory cells and increase chemotactic factors
MoA of Leflunomide
Pyrimidine synthesis inhibitor
MoA of Hydroxychloroquine
induces apoptosis of inflammatory cells and decrease chemotaxis
Side effects of Methotrexate
- hepatitis, cirrhosis, pneumonitis, rash, ulcers, reduction of white blood cells,
- it's teratogenic
What should be done whilst on Methotrexate?
- on contraceptives
- Regular LFTs and FBCs
Name some Anti-TNFs?
How are Anti-TNFs given?
How can Anti-TNFs become more effective?
by being taken alongside DMARDS
What are side effects of Anti-TNFs?
Risk of infection, especially TB
MoA of Anti-TNFs
They suppress the physiologic response to tumour necrosis factor (TNF), which is part of the inflammatory response.
Name some Biologics
MoA of Rituximab
monoclonal antibody against B lymphocytes
MoA of Tocilizumab
MoA of Abatacept
composed of CTLA-4 Ig- that blocks activation of T lymphocytes
MoA of Ustekinumab
inhibits IL12 and IL23
MoA of Secukinumab
Name some urate-lowering drugs