MSK Drugs Flashcards Preview

The Holy Grail (Drugs) > MSK Drugs > Flashcards

Flashcards in MSK Drugs Deck (40)
Loading flashcards...
1

Name some NSAIDs

Ibuprofen
Aspirin
Naproxen
Diclofenac
Indometacin
Etodolac
Celecoxib

2

When to use Etodolac?

symptomatic relief of osteoarthritis and rheumatoid arthritis.

3

Side Effects of Indometacin?

headache, dizziness, and gastro-intestinal disturbances

4

When to use Celecoxib?

relief of pain in osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis

5

MoA of Ibuprofen

It is a propionic acid derivative with anti-inflammatory, analgesic, and antipyretic properties.

6

MoA of NSAIDS

They reduce the production of prostaglandins by inhibiting the enzyme cyclo-oxygenase.

7

Why do you need to stay on NSAIDS for a while?

Pain relief starts soon after taking the first dose and a full analgesic effect should normally be obtained within a week, whereas an anti-inflammatory effect may not be achieved (or may not be clinically assessable) for up to 3 weeks.

8

Why is Naproxen good to use in clinical practice?

because it combines good efficacy with a low incidence of side-effects

9

When are NSAIDS contraindicated?

Asthmatics
GI patients- prescribe in combination with a PPI to protecti GI tract.

10

Name some Analgesics

Paracetamol
Codeine
Co-codamol
Dihyrocodeine
Tramadol
Amytriptyline
Gabapentin
Morphine

11

Name some Disease Modifying Anti-Rheumatoid Drugs (DMARDS)

Methotrexate
Sulphasalazine
Leflunomide
Hydroxychloroquine

12

MoA of Methotrexate

inhibition of enzymes involved in purine metabolism

13

MoA of Sulphasalazine

Suppression of IL-1 & TNF-alpha, induce apoptosis of inflammatory cells and increase chemotactic factors

14

MoA of Leflunomide

Pyrimidine synthesis inhibitor

15

MoA of Hydroxychloroquine

induces apoptosis of inflammatory cells and decrease chemotaxis

16

Side effects of Methotrexate

- hepatitis, cirrhosis, pneumonitis, rash, ulcers, reduction of white blood cells,
- it's teratogenic

17

What should be done whilst on Methotrexate?

- on contraceptives
- Regular LFTs and FBCs

18

Name some Anti-TNFs?

Etanercept
Adalimumab
Certolizumab
Infliximab
Golimumab

19

How are Anti-TNFs given?

Subcutaneous injection

20

How can Anti-TNFs become more effective?

by being taken alongside DMARDS

21

What are side effects of Anti-TNFs?

Risk of infection, especially TB

22

MoA of Anti-TNFs

They suppress the physiologic response to tumour necrosis factor (TNF), which is part of the inflammatory response.

23

Name some Biologics

Rituximab
Tocilizumab
Abatacept
Ustekinumab
Secukinumab

24

MoA of Rituximab

monoclonal antibody against B lymphocytes

25

MoA of Tocilizumab

inhibits IL6

26

MoA of Abatacept

composed of CTLA-4 Ig- that blocks activation of T lymphocytes

27

MoA of Ustekinumab

inhibits IL12 and IL23

28

MoA of Secukinumab

inhibits IL17

29

Name some urate-lowering drugs

Allopurinol
Febuxostat

30

When would you use Febuxostat?

For those who cannot tolerate allopurinol