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Flashcards in Child Health Drugs Deck (15)
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1

What is the function of Orlistat

Its primary function is preventing the absorption of fats from the human diet by acting as a lipase inhibitor, thereby reducing caloric intake.

2

Whats the MoA of Orlistat

Orlistat works by inhibiting gastric and pancreatic lipases, the enzymes that break down triglycerides in the intestine. When lipase activity is blocked, triglycerides from the diet are not hydrolyzed into absorbable free fatty acids, and instead are excreted unchanged. Only trace amounts of orlistat are absorbed systemically; the primary effect is local lipase inhibition within the GI tract after an oral dose. The primary route of elimination is through the feces.

3

Name a Lipase Inhibitor

Orlistat

4

Name side effects of Orlistat

GI problems (steatorrhea etc)

5

Name contraindications for Orlistat

Pregnancy / breastfeeding

6

Name some Nucleoside analog reverse-transcriptase inhibitors (NRTIs)

Abacavir and lamivudine

7

What is the MoA of NRTIs

They inhibit viral replication

8

Name a Non-nucleoside reverse transcriptase inhibitor (NNRTI)

efavirenz

9

MoA of efavirenz

works by blocking the function of reverse transcriptase

10

Name types of antiretrovirals

NRTIs, NNRTIs and protease inhibitors

11

Name some protease inhibitors

Lopinavir and ritonavir

12

The combination of Lopinavir and ritonavir is known as

HAART (Highly active antiretroviral therapy)

13

MoA of protease inhibitors

Inhibit a particular liver enzyme that normally metabolizes protease inhibitors

14

MoA of Artemisinin-based combination therapy

Works by attacking multiple parasite proteins

15

MoA of Artesunate

It causes malarial protein damage