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RUSVM Virology > Paramyxoviridae > Flashcards

Paramyxoviridae Flashcards

1
Q

Clinical sings of NIPAH virus in older animals ( > 6 months)

A

Acute fever

Neurologic signs

Open mouthed breathing

Sialorrhea

Abortions

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2
Q

Bovine Parainfluenza Virus 3

A

Cattle and Sheep

Respiratory Disease

Cessation of ciliary beating predisposes to secondary bacterial infection

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3
Q

Ribonucleoproteins (RNP) assciated with paramyxoviruses

A

RNA binding protein

Phosphoprotein

Large Polymerase

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4
Q

Diagnosis of Newcaste Disease

A

Inoculation of embryonated specific pathogen free eggs and test for hemagglutination activity

ELISA

PCR

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5
Q

Syncytia, cytoplasmic acidophilic inclusion bodies and acidophilic intranuclear inclusion bodies are histologic findings due to the replication of what type of viruses

A

Paramyxoviruses

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6
Q

Replication of paramyxoviruses occurs

A

In the cytoplasm of infected cells

_________________

Also in the presence of actinomycin D or in enucleated cells - no nuclear function is required

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7
Q

Diagnose NIPAH virus

A

Virus isolation - African Green Monkey Kidney and Rabbit Kidney Cells

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8
Q

Transmssion of Newcastle Disease Virus

A

Direct Contact

Fomites

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9
Q

5 Pathotypes of Newcastle Disease Virus

A

Viscerotropic Velogenic

Neurotropic Velogenic

Mesogenic

Lentogenic

Asymptomatic

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10
Q

Diagnosis of Canine Distemper

A

Virus isolation

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11
Q

Characteristics of the Mesogenic Strain of Newcastle Disease

A

Acute respiratory disease with neurological signs

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12
Q

NIPAH Virus

A

Newly emerging zoonosis

Causes encephalitis and respiratory illness

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13
Q

Newcastle Disease Virus belongs to what paramyxovirus genus

A

Avulavirus

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14
Q

Pathogenesis of Canine Distemper

A
  • Virus replicates in upper respiratory tract macrophages
  • Spreads to tonsils and lymph nodes
  • Infects all cells expressing CD150 - signal lymphocyte activation
  • Enters blood stream and infects T and B cells
  • Infection of lungs, bladder , skin
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15
Q

Important role in the pathogenesis of paramyxoviruses

A

Spike glycoproteins

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16
Q

Clinical signs of NIPAH virus in young pigs (1-6 months old)

A

Acute fever

Respiratory signs

Labored breathing

Nasal discharge

Loud non productive cough

Muscle fasciculation, myoclonus, limb weakness and spastic paralysis

17
Q

Characteristics of the Lentogenic Strain of Newcastle Disease Virus

A

Associated with subclinical disease, mild respiratory signs

18
Q

Clinical sign of what paramyxovirus disease

A

Canine Distemper

Canine Distemper Virus

19
Q

Characteristics of the Velogenic Strain of Newcastle Disease

A

Severe disease in chickens

Respiratory and Nervous System Signs

Ruffled feathers, oedema

Green or white watery diarrhea, dyspnea and inflammation of the head and neck often with cyanotic discoloration

Wing/leg paresis or paralysis, torticollis and aberrant circuling behavior

Sharp drop in egg production - eggs contain watery albumin

Sudden death

20
Q

Canine Distemper Virus belongs to what paramyxovirus genus

A

Morbilivirus

21
Q

Newcastle Disease

A

10 serotypes

5 pathotypes

Chickens highly susceptible

Wild brids and waterfowl harbor virus

Zoonotic

22
Q

Barking Pig Syndrome

Porcine Respiratory and Encephalitis Syndrome

Porcine Respiratory and Neurologic Syndrom

A

Disease in pigs caused by NIPAH Virus

23
Q

Clinical features of Canine Distemper

A

Inappetence

Fever

Respiratory Tract Infections

Conjunctivitis

GI Signs

Neurological signs - indicate poor prognosis

Hyperkeratosis

24
Q

T/F: NIPAH Virus can be used as a biological weapon

A

True

25
Q

NIPAH virus causes what in pigs

A

Severe respiratory disease

26
Q

Clinical sign of what paramyxovirus disease

A

Newcastle Disease

Newcastle Disease Virus

27
Q

Which Newcastle Disease Virus strain is distributed worldwide

A

Lentogenic

28
Q

Membrane Proteins of Paramyxoviruses

A

Unglycosylated Matrix Protein

Fusion protein

Attachment Protein Hemagglutinin

29
Q

Transmission of Canine Distemper Virus

A

Shed in all secretions and excretions after 5th day of infection

Virus stable in environment

30
Q

Paramyxovirus virion properties

A

Pelomorphic

Enveloped

“Herringbone” shaped nucelocapsid

Linear, single stranded (-) sense RNA

31
Q

NIPAH virus causes what in humans

A

Severe, rapidly progressive encephalitis

32
Q

Clinical signs of NIPAH virus in suckling pigs and piglets (< 1 month old)

A

Labored breathing

Muscle tremors

Limb weakness

33
Q

NIPAH virus is what biosafety level

A

Biosafety level 4 agent

34
Q

Transmission of NIPAH virus is via

A

Flying Foxes - Fruit Bats

35
Q

Lesions associated with velogenic strains of newcastle disease

A

Swelling of periorbital area or entire head

Edema of interstital or peritracheal tissue of neck

Edema, hemorrhage or degeneration of ovaries

Edema, hemorrhage, necrosis or ulceration of respiratory/digestive lymphoid tissue

36
Q

NIPAH virus is a memeber of what paramyxovirus genus

A

Henipavirus

37
Q

Impact of Paramyxoviruss has been reduced beacuse of

A

Vaccination

38
Q

Canine Distemper Virus

A

Highly contagious, acute febrile disease of dogs

RUSVM Virology (35 decks)

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