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RUSVM Virology > Flaviviridae > Flashcards

Flaviviridae Flashcards

1
Q

Classical Swine Fever virus is transmitted by

A

Oronasal route

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2
Q

Infection with BVDV can result in what clinically different disease syndromes

A

Bovine Viral Diarrhea

Mucosal Disease

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3
Q

Genera of Flaviviridae

A

Flavivirus

Pestivirus

Hepacivirus

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4
Q

Diagnosis of BVDV

A

Clinical history and signs

Virus isolation in cell culture

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5
Q

Diagnosis of Classical Swine Fever

A

Clinical Signs

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6
Q

Characteristics of chronic mucosal disease

A

Skin ulcers, areas of hyperkeratosis and necrosis of crypt enterocytes

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7
Q

West Nile Virus is maintained in

A

Mosquitos and Birds

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8
Q

Characteristics of postnatal BVDV infection in non-pregnant cattle

A

Most common in young animals

Milid clinical disease

Biphasic fever, leukopenia, diarrhea, ulceration on lips/mouth/oral cavity, decreased milk production, thrombocytopenia

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9
Q
A
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10
Q

Clinical sign of what disease pattern of BVDV

A

Chronic mucosal disease

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11
Q

Diagnosis of West Nile Virus

A

IgM ELISA

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12
Q

Cytopathic BVDV

A

Induce cytopathic effect in infected cells

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13
Q

Non Cytopathic BVDV

A

Cause persistent infection

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14
Q

Characteristics of BVBD infection in pregnant cows

A

Transplacental spread to fetus

Disease depends on fetus age:

  • Early- embryonic death/reabsorption
  • Before Immunological Competence - destructive fetal lesions, persistent postnatal infection, retarded growth “weak calf syndrome”, congenital defects
  • Late- carriers of virus, seronegative.
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15
Q

Clinical signs of West Nile Virus

A

Various Neurological Signs

Fever

Abnormal Gait

Head tremors

Muscle Fasciculation

Ataxia

Recumbance

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16
Q

Mucosal Disease caused by BVDV

A

Sporadic disease occuring in persistently infected animals, usually as an aftermath of an epizootic infection

17
Q

Bovine Viral Diarrhea Virus (BVDV) belong to the genus

A

Pestivirus

18
Q

Pathogenesis of BVDV mucosal disease

A

Develop after infection with both non-cytopathic and cytopathic biotypes

Virus replicates throughout the GI tract and lymph nodes

Erosion or ulcers in mucosal epitheilum

19
Q

Clinical sign of what disease pattern of BVDV

A

Post natal infection in non pregnant cattle

20
Q

Bovine Viral Diarrhea

A

Acute disease, epizootic in nature in naive animals

21
Q

Primary replication site of Classical Swine Fever Virus

A

Tonsils

22
Q

Clinical signs of what Flavivirus

A

Classical Swine Fever Virus

23
Q

Lineages of West Nile Virus

A

WNV 1 and WNV 2

24
Q

Characteristics of persistant BVDV infection in calves and mucosal disease

A

Caused by non cytopathic virus

Failure to thrive

Mucosal disease develops when co-infected with cytopathic virus

25
Q

Secondary site of replication for Classical Swine Fever Virus

A

Lymphoid Tissue

26
Q

Clinical features of Classical Swine Fever Virus

A

Diffuse hyperemia, nervous system signs, lethargy, paralysis, tremors and convulsions

27
Q

Transmission of BVDV

A

Indirectly

Directly from persistently infected animals

28
Q

BVDV mucosal disease is manifested by

A

Fever, anorexia, profuse watery diarrhea, erosion or ulcerative stomatitis

29
Q

Flaviviruses are inactivated by

A

Heat, common disinfectants, lipid solvents

30
Q

Clinical signs of what disease pattern of BVDV

A

Persistent infection in calves and mucosal disease

31
Q

Disease patterns arising for BVDV infection

A

Postnatal infection in non-pregnant cattle

Infection in pregnant cows

Persistent infection in calves and mucosal disease

32
Q

Replication of Flaviviruses occurs in the

A

Cytoplasm

33
Q

West Nile Virus is fatal in what species

A

Birds

34
Q

Pathogenesis of postnatal BVDV infection

A

Respiratory

Replication in nasal mucosa and tonsils to lymph nodes and then to intestines

35
Q

West Nile Virus belongs to genus

A

Flavivirus

36
Q

Characterisistics of Flavivirus

A

Enveloped

Single Stranded RNA

Positive Sense

Infectious RNA

RUSVM Virology (35 decks)

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