Blocking Drugs - 2 Flashcards Preview

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Flashcards in Blocking Drugs - 2 Deck (33)
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1

What are the 6 inhaled anesthetics? 

Desflurane

Enflurane

Halothane

Isoflurane

Sevoflurane

Nitrous oxide

2

Facilitate GABA-mediated inhibition: block brain NMDA and ACh-N receptors

MOA of which drug? 

All inhaled anesthetics

3

inhaled anesthetics increase ___________. 

inhaled anesthetics increase cerebral blood flow

4

Which two drugs decrease cardiac output? 

All others cause vasodilation

enflurane & halothane

5

all inhaled anesthetics decrease ________. 

all inhaled anesthetics decrease respiratory functions. 

6

Which drug causes lung irritation? 

desiflurane

7

Rate of onset and recovery vary by blood: gas partition coefficient

recovery mainly due to redistribution from brain to other tissues

P-kinetics of which drug? 

inhaled anesthetics

8

What are the toxicities of inhaled anesthetics

extensions of effects on brain, heart/vasculature, lungs. 

9

What are the drug interactions of inhaled anesthetics? 

additive CNS depression with many agents, especially opioids and sedative-hypnotics

10

What plays an important role in the practice of modern anesthesia?

IV non-opioid anesthetics

11

Used to facilitate rapid induction of anesthesia and have replaced inhalation as the preferred method of anesthesia induction in most settings except for pediatric anesthesia

Which drugs? 

IV Anesthetics

12

Provide sedation during monitored anesthesia care and for patients in intensive care (ICU) settings.

Which drug? 

IV Anesthetics

13

Not ideal anesthetic drugs in the sense of producing all and only the five desired effects (unconsciousness, amnesia, analgesia, inhibition of autonomic reflexes, and skeletal muscle relaxation)

Which drug? 

IV Anesthetics

14

What 4 drugs facilitate GABA-mediated inhibition of Gaba-A receptors? 

Barbiturates, benzodiazepines, etomidate, and propofol 

15

facilitate GABA-mediated inhibition at GABAA receptors

 

MOA of which drug? 

Thiopental, Thioamylal, Methohexital

16

Pharmacologic effects of Thiopental, Thioamylal, Methohexital (Barbiturates)

Circulatory and respiratory depression

decrease intracranial pressure

17

High lipid solubility—fast onset and short duration due to redistribution

PK of which drug? 

Barbiturates: 

Thiopental, Thioamylal, Methohexital

18

Extensions of CNS depressant actions

additive CNS depression with many drugs

Toxicities and Interactions of which drug? 

Barbiturates: 

Thiopental, Thioamylal, Methohexital

19

Slower onset, but longer duration than barbiturates

Which drug? 

Midazolam 

20

Postoperative respiratory depression reversed by flumazenil

Toxicities and Interactions of which drug? 

Midazolam

21

Blocks excitation by glutamate at NMDA receptors

MOA of which drug? 

Ketamine

22

What are the pharmacologic effects of ketamine? 

analgesia, amnesia and catatonia but consciousness retained

CV stimulation

23

PK of ketamine? 

Moderate duration of action—hepatic metabolism

24

Pharmacologic effects of Etomidate

Minimal effects on CV and respiratory functions

25

PK of Etomidate

Short duration due to redistribution

26

What are the 4 opioids? 

Fentanyl

 Alfentanil

 Remifentanil

 Morphine

27

Interact with μ, κ, and δ opioid receptors

 

MOA of which drug? 

Opioids:

Fentanyl

 Alfentanil

 Remifentanil

 Morphine

28

Pharmacologic Effects of Opioids

Marked analgesia, respiratory depression

29

PK of opioids

Alfentanil and remifentanil: fast onset (induction)

30

What are the 2 phenols? 

Propofol

Fospropofol