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Flashcards in Antiemetic popcorn Deck (33)
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1

What 4 receptors are involved in the "Chemoreceptor trigger zone"

D2 (dopamine)

opioid

5-HT3 (serotonin)

NK1 (neurokinin)

2

Which 2 receptors are involved in the vestibular system

M1 and H1

Involved in motion sickness

 

("Meghan Markle and Prince Harry get motion sickness")

3

Which receptor is in the vagal and spinal afferent nerves in the GI tract

5-HT3

(so not involved in motionsickness)

4

T/F: complex N/V is resolved with antiemetics

false

5

What are the 4 Selective Serotonin 5-HT3 receptor antagonists?

1. Granisetron

2. Ondansetron

3. Dolasetron

4. Palonosetron

 

("Palo GOD")

6

Which Selective Serotonin 5-HT3 receptor antagonist causes QT prolongation

Dolasetron

7

Which Selective Serotonin 5-HT3 receptor antagonist do you have to decrease in liver problems

Ondansetron

8

What are the 2 uses of Selective Serotonin 5-HT3 receptor antagonists? What is it not useful for (2)?

  • Uses: Chemo, post-op
  • NOT FOR MOTION SICKNESS
  • NO use for N/V 24hrs after chemo

9

Is dose reduction of Selective Serotonin 5-HT3 receptor antagonists required in geriatric patients with renal insufficiency?

no

10

How do you increase efficacy of Selective Serotonin 5-HT3 receptor antagonists?

add corticosteroid (Methylprednisolone)

11

What are the 2 ADEs of Selective Serotonin 5-HT3 receptor antagonists

HA

constipation (slow GI motility)

12

What are the 2 Substance P/NK1 receptor antagonist meds?

Aprepitant

Rolapitant

13

What are Substance P/NK1 receptor antagonists used for?

Delayed emesis

14

How do you treat acute and delayed emesis?

Substance P/NK1 receptor antagonists + Selective seretonin receptor blocker

= Netupitant + Palonosetron

15

Which group of meds have hiccups as a SE?

Substance P/NK1 receptor antagonists

(Aprepitant, Rolapitant)

16

Which antihistaminic/anticholinergic should not be used in elderly

Dimenhydrinate

17

What are the 2 uses of Meclizine 

Vertigo

Motion sickness

18

What med should be used for motion sickness on a cruise?

(KNOW)

Scopolamine

19

What are the 2 ADEs of Prochlorperazine?

Prolonged QT

Tardive Dyskinesia

20

2 ADEs of Promethazine

Sedation 

Drowsiness

21

What is the main ADE of Chlorpromazine?

Tardive Dyskinesia

22

Which med should you be careful giving to patients in extremely hot/cold climates due to the Difficulty regulating body temp 

Chlorpromazine

23

What is the MOA of Chlorpromazine

Hypothalamus depression affecting basal metabolism, body temp, wakefulness, ,emesis

24

What receptor does Haloperidol and Droperidol block?

D2

(Group= Butyrophenones)

25

Which Butyrophenon (D2 blocker) causes QT prolongation/Torsades, requires EKG to monitor but has limited use outside trials

Droperidol

26

What 2 Benzos are used to tx anticipatory N/V?

What schedule drug?

  • Alprazolam, Lorazepam
  • Schedule IV

("You get anticipatory N/V when you go to LA for 4 weeks

27

Main SE of Alprazolam?

memory impairment

28

What schedule are Cannabinoids?

Schedule III

29

What is the main SE of Dronabinol (cannabinoid) that most patients don't like

euphoria

30

What are the 3 SEs of Nabilone (cannabinoid)

Somnolence

Vertigo

Xerostomia