Names of SSRIs
Lithium, TCAs, warfarin alprazolam, theophylline cause Increased blood levels
PK and drug interactions of which drug?
What toxicity is associated with SSRIs?
Doses greater than 40 mg/day not recommended due to QT prolongation
maximum daily dosage = 20mg for CYP2C19 poor metabolizers
What ADR is common to all antidepressants and what must you monitor for due to this?
Monitor: behavioral changes, mental status
What is the black box warning on all antidepressants?
caregivers should be alerted to monitor for acute changes in behavior (especially early in treatment)
Which additional ADRs are common to all SSRIs?
Anxiety or nervousness
Which SSRI may be more activating (keeping you awake)?
Which SSRIs may be more sedating?
What is the main ADR of citalopram?
OT interval prolongation
What is the main ADR of fluoxetine?
What is the main ADR of fluvoxamine?
What is the main ADR of paroxetine?
Indications of SNRIs?
Pain disorders: neuropathies and fibromyalgia
Stress urinary incontinence
Vasomotor symptoms of menopause
What are the 4 SNRIs?
What is the toxicity of venlafaxine?
What is the main ADR common to all SNRIs?
CV changesL inc. BP; hearr rate
What is the main ADR to Desvenlafaxine?
What is the main ADR to venlafaxine?
Indications for 5-HT2 receptor antagonists?
Combo SSRI & 5-HT1A
Inhibits 5-HT, a 5-HT1A agonist and a 5-HT3 receptor antagonist
What mixed 5-HT would you use for depressed pts with anxiety?
Which mixed 5-HT should you use with pt with depression & cognitive difficulties?
Bupropion is an _____.
Bupropion is an NDRI (norepinephrine and dopamine reuptake inhibitor)
Mirtazapine is a ___________
serotonin and alpha 2 receptor antagonist
What are the 4 heterocyclics?
What heterocyclic can you use for smoking cessation?
PK of heterocyclics
Which 2 heterocyclics lower seizure threshold (toxicity)?