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Flashcards in Antidepressants 2 Deck (47)
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1

Names of SSRIs

Citalopram 

Escitalopram

Fluoxetine

Paroxetine 

Sertraline 

2

Lithium, TCAs, warfarin alprazolam, theophylline cause Increased blood levels

PK and drug interactions of which drug? 

SSRIs

3

What toxicity is associated with SSRIs? 

sexual dysfunction

4

Doses greater than 40 mg/day not recommended due to QT prolongation

maximum daily dosage = 20mg for CYP2C19 poor metabolizers

which drug? 

Citalopram

5

What ADR is common to all antidepressants and what must you monitor for due to this? 

ADR: suicidality

Monitor: behavioral changes, mental status

 

6

What is the black box warning on all antidepressants? 

caregivers should be alerted to monitor for acute changes in behavior (especially early in treatment)

7

Which additional ADRs are common to all SSRIs? 

Anxiety or nervousness

Insomnia

Nausea

Serotonin syndrome

Sexual dysfunction

8

Which SSRI may be more activating (keeping you awake)? 

Fluoxetine

9

Which SSRIs may be more sedating? 

fluvoxamine

paroexetine

10

What is the main ADR of citalopram? 

OT interval prolongation

11

What is the main ADR of fluoxetine? 

anorexia

12

What is the main ADR of fluvoxamine? 

somnolence

13

What is the main ADR of paroxetine? 

anticholinergic effects

14

Indications of SNRIs? 

MDD

GAD

Pain disorders: neuropathies and fibromyalgia

Stress urinary incontinence

Vasomotor symptoms of menopause

15

What are the 4 SNRIs? 

Venlafaxine

Desvenlafaxine

Duloxetine

Levomilnacipran

16

What is the toxicity of venlafaxine? 

HTN

17

What is the main ADR common to all SNRIs? 

CV changesL inc. BP; hearr rate

18

What is the main ADR to Desvenlafaxine? 

dose-related hyperlipidemia

19

What is the main ADR to venlafaxine? 

dose-related HTN

20

Indications for 5-HT2 receptor antagonists? 

MDD

hypnotic

21

Combo SSRI & 5-HT1A

which drug? 

Vilazodone

22

Inhibits 5-HT, a 5-HT1A  agonist and a 5-HT3 receptor antagonist

which drug? 

Vortioxetine

23

What mixed 5-HT would you use for depressed pts with anxiety? 

Vilazodone

24

Which mixed 5-HT should you use with pt with depression & cognitive difficulties? 

Vortioexetine

25

Bupropion is an _____. 

Bupropion is an NDRI (norepinephrine and dopamine reuptake inhibitor)

26

Mirtazapine is a ___________

serotonin and alpha 2 receptor antagonist

27

What are the 4 heterocyclics? 

amoxapine

bupropion

maprotiline

mirtazepine

28

What heterocyclic can you use for smoking cessation? 

bupropion

29

PK of heterocyclics

hepatic metabolism

30

Which 2 heterocyclics lower seizure threshold (toxicity)? 

amoxapine, bupropion