What are the 4 essentials of diagnosis for anxiety?
Overt anxiety or an overt manifestation of a coping mechanism (such as a phobia) or both
Not limited to an adjustment disorder
Somatic symptoms referable to the autonomic nervous system or to a specific organ system (eg, dyspnea, palpitations, paresthesias)
Not a result of physical disorders, psychiatric conditions (eg, schizophrenia), or drug abuse (eg, cocaine)
What are common CV medical illnesses associated with anxiety sx?
congestive heart failure
ischemic heart disease
mitral valve prolapse
What are common endocrine & metabolic illnesses associated with anxiety sx?
vitamin B12 or folate deficiencies
What are common GI illnesses associated with anxiety sx?
irritable bowel syndrome
peptic ulcer disease
What are common Neurological medical illnesses associated with anxiety sx?
poor pain control
What are common Respiratory system illnesses associated with anxiety sx?
Asthma, chronic obstructive pulmonary disease, pulmonary embolism, pneumonia
What are the 5 1st line drugs for GAD
What are the 4 2nd line drugs for GAD?
Alternative drugs for GAD
1st line drugs for panic disorder?
2nd line for panic disorder?
Alternative drugs for panic disorder?
6 1st line drugs for social anxiety d/o?
Social anxiety disorder
2nd line drugs for social anxiety disorder?
Alternative drugs for social anxiety disorder?
partial agonist at 5-HT receptors and possibly D2 receptors
interacts with the 5-HT1A subclass of brain serotonin receptors as a partial agonist
minimal CNS depressant effects (it does not affect driving skills)
no anticonvulsant or muscle relaxant properties
MOA of which drugs?
What are the PK of anxiolytics?
slow onset of action (>1 week)
forms active metabolite
interactions with CYP3A4 inducers and inhibitors
Indications for using Buspirone?
used in GAD
less effective in panic disorders
Adverse effects of Buspirone
GI distress, tachycardia
Dependency of Buspirone
tolerance development is minimal with chronic use
little rebound anxiety or withdrawal symptoms on discontinuance
Is Buspirone safe in pregnancy?