Hepatotoxicity Flashcards
1
Q
What percentage of Caucasians are slow acetylators?
A
50%
2
Q
Erythromycin estolate is associated with hepaticellular necrosis
A
F
Cholestasis
3
Q
Cyp P450 enzymes produce only a small increase in hydrophilicity of drugs metabolized
A
T
They are phase 1 enzymes and largely oxidate i.e. add hydroxyl group
4
Q
% Caucasians with no 2D6 activity
A
10%
