31. Psychotropic Agents Flashcards

1
Q

One unique effect of alprazolam is its antidepressant effect

A

T

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2
Q

Buspirone can be used on a PRN basis

A

F

Takes 2-4 weeks onset of action

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3
Q

Doxepin has strong antipruritic effects as it is a very powerful H1 antihistamine

A

T

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4
Q

Alprazolam is indicated for acute and self limited stress

A

T

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5
Q

There is a 50 fold difference in trough blood levels among ind on same dose doxepin

A

T

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6
Q

Doxepin is metabolize by cyp3a4

A

F

2D6

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7
Q

Doxepin is associated with hypertension and weight loss

A

F
Hypotension
Weight gain
Cardiac conduction disturbance

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8
Q

Which drugs require pre treatment ECG

A

Doxepin

Pimozide

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9
Q

What are the discontinuation symptoms of stopping TCAs?

A
Uncomfortably vivid dreams
Transient dizziness
Nausea
Headache
Diaphoresis
Insomnia
Malaise
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10
Q

Patients showing no improvement after 2 weeks should switch to another Ssri

A

F

6 weeks

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11
Q

SSRIs have 5% incidence sexual difficulties

A

F

40%

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12
Q

Switching to another class of antidepressants is appropriate when sexual adverse effects occur . Which class had less sexual dysfunction ?

A

Bupropion

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13
Q

Discontinuation symptoms can occur with SSRIs and venlafaxine

A

T
Taper off slowly
Rather than abruptly

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14
Q

Bupropion is not associated with seizure induction

A

F

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15
Q

Long term Pimozide use is best avoided to minimisr risk of tardive dyskinesia

A

T

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16
Q

Most common side effects of risperidone are anxiety dizziness and rhinitis

A

T

17
Q

There is a 50 fold difference in trough blood levels among ind on same dose doxepin

A

T

18
Q

Doxepin is metabolize by cyp3a4

A

F

2D6

19
Q

Doxepin is associated with hypertension and weight loss

A

F
Hypotension
Weight gain
Cardiac conduction disturbance

20
Q

Which drugs require pre treatment ECG

A

Doxepin

Pimozide

21
Q

What are the discontinuation symptoms of stopping TCAs?

A
Uncomfortably vivid dreams
Transient dizziness
Nausea
Headache
Diaphoresis
Insomnia
Malaise

MINDHUrT

22
Q

Patients showing no improvement after 2 weeks should switch to another Ssri

A

F

6 weeks

23
Q

SSRIs have 5% incidence sexual difficulties

A

F

40%

24
Q

Switching to another class of antidepressants is appropriate when sexual adverse effects occur . Which class had less sexual dysfunction ?

A

Bupropion

25
Q

Discontinuation symptoms can occur with SSRIs and venlafaxine

A

T
Taper off slowly
Rather than abruptly

26
Q

Bupropion is not associated with seizure induction

A

F

27
Q

Long term Pimozide use is best avoided to minimisr risk of tardive dyskinesia

A

T

28
Q

Most common side effects of risperidone are anxiety dizziness and rhinitis

A

T

29
Q

Most common ssri side effect is weight gain

A

F

Nausea and diarrhoea

30
Q

Pimozide is a potent centrally acting dopamine receptor agonist

A

F

Dopamine rec antagonist

31
Q

Venlafaxine has no sexual dysfunction

A

F

Less than SSRIs though

32
Q

Most common se of venlafaxine

A

Nervousness anxiety insomnia

33
Q

Bupropion is a weak inhibitor of dopamine re uptake

A

T

34
Q

Doxepin has a much higher affinity for histamine receptors than traditional antihistamines

A

T

35
Q

Night time dose of doxepin provides therapeutic benefit for 24h

A

T