IL12/23 inhibitors Flashcards
1
Q
ustekinumab is a fully human, IgG1 antibody
A
T
2
Q
ustekinumab has a high affinity and specificity against the P50 subunit of IL-12 and IL-23
A
False
p40 subunit
3
Q
Secukinumab selectively neutralizes IL-17A
A
T
4
Q
ustekinumab inhibits interaction of IL-12RB1 with the p40 subunit of IL-12 and IL-23,
This inhibits activity of both interleukins on T cell differentiation and cytokine production
A
T
5
Q
The common p40 subunit is over expressed in psoriatic plaques
A
T
6
Q
Human derived mabs should be more immunogenic than chimeric
A
F
Less
7
Q
Patients with IgE syndrome (Job’s) have defects in Th17 but not Th1 cells
A
T
Prone to S. Aureus abscesses , chronic candidiasis , pulmonary infections
