Antihistamines Flashcards
Q1.
Regarding cetirizine:
a.
It significantly interacts with erythromycin
b.
Levocetirizine is a pharmacologically active metabolite
c.
It has NO effect on eosinophils
d.
It is less likely to cause sedation than loratadine
e.
It is a carboxylic acid metabolite of hydroxyzine
F T F F T
First generation antihistamines consisted of ethers based on imidazole ring structure of antihistamine
True
First generation antihistamines do not bind significantly to H2/3 receptors
True
First generation antihistamines are relatively hydrophilic
False
Lipophilic
First generation antihistamines cross the BBB
True
First and second gen antihistamines are H1 inverse agonists
T
Second generation antihistamines have moderate propensity to induce drowsiness
False
Negligible
Cetirisine is the carboxylic acid metabolite of hydroxyzine
T
Decreased tissue antihistamine has been reported in involved skin of chronic urticaria
F
Loratidine may cause cardiac dysrhythmias
F
Does not cause dysrhythmias
Lowering dose of loratidine is recommended in chronic renal or hepatic disease
T
Loratidine is short acting
F
Long acting H1 antihistamine
Deslorstidine is 5 x more potent as suppressing wheal than loratidine
T
Loratidine may cause cardiac dysrhythmias
F
Does not cause dysrhythmias
Lowering dose of loratidine is recommended in chronic renal or hepatic disease
T
