Opsonization and Phagocytosis - can Flashcards Preview

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Flashcards in Opsonization and Phagocytosis - can Deck (14)
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1

What are Opsonins?

Macromolecules attached to the surface of a microbe and can be recognized by receptors on neutrophils and macrophages. *Most microorganisms will NOT be phagocytes without opsonins.

2

What are the receptors for Opsonins?

- Fcy on phagocytes
- Cr and leukocytes intergrein Mac-1

3

In regards to IgG receptors,____ regions react with organisms.

Fab

4

_______ is the signal for macrophages to phagocytose the neutrophils.

The loss of CD16

5

_______ is most important for phagocytosis of IgG coated particles and microorganisms.

RII

6

What are the Chemotactic factors?

C3a & C5a

7

What are the main complement derived opsonins?

C3b & C3bi

8

Monocytes are found where vs macrophages?

Monocytes in blood, move to tissue and become macrophages *Phagocytic function

9

What is the major phagocytic cell of the innate immune system?

Neutrophils

10

What factors increase PMN #s?

stress
injury
infection
Increased cytokines

11

2 main methods of destruction of bacteria?

- oxidative mechanism
- Non-oxidative (Enzymes & pH change)

12

What kinds of receptors are found on macrophages?

Similar to neutrophils:
- LPS receptor (CD14)
- Toll like receptors
- Fe receptors
- Complement receptors
- IFNy receptor
- Chemokine receptors

13

5 kinds of phagocytic cells...GO!

1. neutrophils
2. Macrophage/monocyte
3. Eosinophils
4. Basophils
5. Dendritic cells

14

3 Tactics used by pathogens to avoid being killed by phagocytes...Go!

1. Kill or be killed (Cytotoxicity)
2. Inhibit opsonization or inactivate phagocytosis
- capsule
- M protein
- Disrupt signaling
3. Survive intracellular killing
- inhibit phagosome-lysomsome fusion
- Escape from phagosome
- survive lysosomal enzymes.