CONDENSED - Cytokines, Chemokines and Receptors - Bailey Flashcards Preview

Micro FINAL EXAM > CONDENSED - Cytokines, Chemokines and Receptors - Bailey > Flashcards

Flashcards in CONDENSED - Cytokines, Chemokines and Receptors - Bailey Deck (22)
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1

Which Cytokines are considered adaptive?

IL-2, IL-4, IL-5 & IL-13

2

Which Cytokines are considered Innate?

TNF-alpha
IL-1
IL-6
IL-12 (Induces INF gamma)
INF gamma

3

What is the primary function of cytokines?

Mediating the immune system

4

What is the main difference between TH1 and TH2 based immunity?

TH1 = works in conjunction with CD8+ cytotoxic t cells and macrophages. - uses INF-gamma that activates macrophages to combat intracellular microbes.

TH2 = works in the in conduction with B cell antibodies, eosinophils and mast cells. - signature cytokines are IL-4,5 & 13 which activates mast cells and eosinophils.
*Both TH1 & TH2 use IL-2.

5

How do Chemokines contribute to Cell migration?

Through a Chemokine gradient to peripheral tissues.

6

_____ is the principal mediator of the acute inflammatory response to Gram - bacteria and stimulates recruitment of monocyte, neutrophils and t cells to site of infection.

TNF-Alpha

7

_______ has alpha and beta type that are the function which is the same function TNF-alpha.

IL-1

8

_____ has same function as TNF-alpha and IL-1.

IL-6

9

______ induces the production of INF-gamma.

IL-10

10

T or false, IL-12 activates macrophages directly.

False JORDAN!

11

_____ is responsible for growth, survival and differentiation of all t cells.

IL-2

12

______ primary function is to facilitate the ability of macrophages to kill intracellular microbes.

IFN-gamma

13

_____ is very similar to IL-4 (structurally and functionally)

IL-13

14

What do both IL-13 and IL-4 do?

Primary job is to help induce Ig isotope switch to IgE

15

_____ inhibits IL-12.

IL-10 (Inhibitory)
*Important because IL-12 does everything.

16

How do Chemokines contribute to Cell migration?

Through a Chemokine gradient to peripheral tissues.

17

What is the Job of IL-5?

Primary job is in eosinophil differentiation , proliferation and activation. * Part in allergic responses also.

18

What cytokines and Chemokines are part of Type I cytokine receptor family?

IL-2, IL-4, IL-5, IL-6, IL-12 and IL-13

19

What cytokines and chemokine are part of Type II cytokine receptor family?

IFN-gamma and IL-10

20

What Cytokines and Chemokines are part of the TNF Receptor Superfamily?

TNF-alpha

21

What cytokines and chemokines are part of the IL-1 Receptor family?

IL-1

22

What cytokines and chemokines are part of the 7 transmembrane G-protein-coupled receptors?

- All of the chemokine receptors
- 7 transmembrane receptors